1. Cell Cycle/DNA Damage
    Anti-infection
  2. DNA/RNA Synthesis
    Bacterial
  3. Streptolydigin

Streptolydigin (Synonyms: Portamycin)

Cat. No.: HY-122337
Handling Instructions

Streptolydigin (Portamycin) is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor with a Ki of 18 μM and a Kd of 15 μM. Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases. Streptolydigin possess potent antibacterial activity, particularly against anaerobes and some Gram-positive aerobes.

For research use only. We do not sell to patients.

Streptolydigin Chemical Structure

Streptolydigin Chemical Structure

CAS No. : 7229-50-7

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Description

Streptolydigin (Portamycin) is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor with a Ki of 18 μM and a Kd of 15 μM. Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases[1][2][3]. Streptolydigin possess potent antibacterial activity, particularly against anaerobes and some Gram-positive aerobes[4].

IC50 & Target

Ki: 18 μM (Bacterial RNA polymerase)[3]
Kd: 15 μM (Bacterial RNA polymerase)[3]

In Vitro

The antibiotic Streptolydigin (Stl) is a derivative of 3-acetyltetramic acid. Binding of Streptolydigin to RNA polymerase strictly depends on a noncatalytic magnesium ion which is likely chelated by the aspartate of the bridge helix of the active center[1].
Streptolydigin inhibits T. thermophilus RNA polymerase with a Ki of 1.8 μM[3].
Streptolydigin (Stl) inhibits initiation, elongation, and pyrophosphorolysis by bacterial RNA polymerase. Streptolydigin interacts with three structural elements within RNAP: the Stl pocket, the bridge helix, and the trigger-loop region. The Streptolydigin streptolol moiety interacts with the Streptolydigin pocket and bridge helix, and the Streptolydigin tetramic-acid moiety interacts with the trigger-loop region[3].

Molecular Weight

600.70

Formula

C₃₂H₄₄N₂O₉

CAS No.

7229-50-7

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

StreptolydiginPortamycinDNA/RNA SynthesisBacterialRNApolymeraseantibioticMg2+aspartateanaerobestranscription3-acetyltetramicacidGram-positiveInhibitorinhibitorinhibit

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Streptolydigin
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