1. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  2. iGluR Lipoxygenase
  3. Osavampator

Osavampator  (Synonyms: TAK-653)

Cat. No.: HY-115864 Purity: 99.89%
COA Handling Instructions

Osavampator (TAK-653) is a AMPA receptor positive allosteric modulator. Osavampator selectively binds to AMPA-R in a glutamate-dependent manner and induces Ca2+ influx in hGluA1i CHO cells (EC50 = 3.3 μM). Osavampator improves learning and memory in many models. Osavampator is can be used for the research of depressive disorders.

For research use only. We do not sell to patients.

Osavampator Chemical Structure

Osavampator Chemical Structure

CAS No. : 1358751-06-0

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Description

Osavampator (TAK-653) is a AMPA receptor positive allosteric modulator. Osavampator selectively binds to AMPA-R in a glutamate-dependent manner and induces Ca2+ influx in hGluA1i CHO cells (EC50 = 3.3 μM). Osavampator improves learning and memory in many models. Osavampator is can be used for the research of depressive disorders[1][2].

IC50 & Target

5-LO

 

In Vivo

Osavampator (0.03-0.3 mg/kg, p.o., single dose) enhances visual learning and memory in normal rats[2].
Osavampator (0.3 mg/kg, p.o., single dose) enhances sustained attention in the poor performing rats[2].
Osavampator (0.06 mg/kg, p.o., single dose) improves working memory in monkeys[2].
Osavampator (1 mg/kg, p.o., single dose) produces antidepressant-like effects in the rat RSBM (reduction of submissive behavior model)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Normal rats[2]
Dosage: 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg
Administration: Oral gavage (p.o.)
Result: Improved the novelty discrimination index (NDI).
Animal Model: Poor performing rats[2]
Dosage: 0.3 mg/kg
Administration: Oral gavage (p.o.)
Result: Increased correct responses and decreased omissions in the poor performing rats.
Animal Model: Fasted monkey[2]
Dosage: 0.06 mg/kg
Administration: Oral gavage (p.o.)
Result: Significantly increased delayed match-to-sample (DMTS) accuracy at a 16-s delay interval.
Maintained the beneficial effect 24 h after administration.
Animal Model: submissive behavior model [1]
Dosage: 0.1 mg/kg, 1 mg/kg
Administration: Oral gavage (p.o.)
Result: Led to a significant reduction in dominance levels compared with vehicle treatment starting from the seventh day of treatment and maintained throughout the study period.
Had a significant effect in reducing dominance levels at 0.1 and 1 mg/kg.
Molecular Weight

373.47

Formula

C19H23N3O3S

CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=S1(N=C2C(C3=CC=C(C=C3)OC4CCCCC4)=NC(C)=CN2CC1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 12.5 mg/mL (33.47 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6776 mL 13.3880 mL 26.7759 mL
5 mM 0.5355 mL 2.6776 mL 5.3552 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.89%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6776 mL 13.3880 mL 26.7759 mL 66.9398 mL
5 mM 0.5355 mL 2.6776 mL 5.3552 mL 13.3880 mL
10 mM 0.2678 mL 1.3388 mL 2.6776 mL 6.6940 mL
15 mM 0.1785 mL 0.8925 mL 1.7851 mL 4.4627 mL
20 mM 0.1339 mL 0.6694 mL 1.3388 mL 3.3470 mL
25 mM 0.1071 mL 0.5355 mL 1.0710 mL 2.6776 mL
30 mM 0.0893 mL 0.4463 mL 0.8925 mL 2.2313 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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