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Products are for research use only. Not for human use. We do not sell to patients.

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TAK-715

HY-10456

(TAK 715; TAK715)

TAK-715

TAK-715 Chemical Structure

TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $83 In-stock
5 mg $75 In-stock
10 mg $110 In-stock
50 mg $330 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €81 In-stock
5 mg €74 In-stock
10 mg €108 In-stock
50 mg €323 In-stock
100 mg Get quote
200 mg Get quote

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Product name: TAK-715
Cat. No.: HY-10456

TAK-715 Data Sheet

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    Purity: 99.97%

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    DataSheet

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Biological Activity of TAK-715

TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.
IC50 value: 7.1 nM [1]
Target: p38α MAPK
in vitro: TAK 715 inhibits LPS-stimulated release of TNF-alpha from THP-1 with IC50 of 48 nM [1]. TAK 715 (10 μM) inhibits Wnt-3a-induced hDvl2 phosphorylation and the hDvl2 shift in U2OS-EFC cells [2]. The amide NH of TAK 715 is hydrogen bonded to the main-chain carbonyl of Met109 of p38 alpha. TAK 715 binds relatively high in the ATP pocket, occupying the hydrophobic back pocket, the adenine region and the front pocket of p38 as well as extending to most of the length of the Gly-rich loop [3].
in vivo: TAK 715 (10 mg/kg, po) inhibits LPS-induced TNF-alpha production in mice with 87.6% inhibition. TAK 715 has a modest mouse bioavailability of 18.4% and a slightly improved rat bioavailability of 21.1%. TAK 715 has a modest mouse bioavailability of 18.4% and a slightly improved rat bioavailability of 21.1%. TAK 715 results in Cmax of 0.19 μg/mL and AUC(0-24 hours) of 1.16 μg·h/mL in rats. TAK 715 (30 mg/kg, po) significantly reduces the secondary paw volume with 25 % inhibition in a rat adjuvant-induced arthritis (AA) model [1].

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 399.51 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C24H21N3OS
CAS No 303162-79-0
Solvent & Solubility

DMSO: >15 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.5031 mL 12.5153 mL 25.0307 mL
5 mM 0.5006 mL 2.5031 mL 5.0061 mL
10 mM 0.2503 mL 1.2515 mL 2.5031 mL

References on TAK-715

Inhibitor Kit

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