1. Cell Cycle/DNA Damage
  2. Deubiquitinase
  3. TCID

TCID (Synonyms: 4,5,6,7-Tetrachloroindan-1,3-dione)

Cat. No.: HY-18638 Purity: 99.76%
Handling Instructions

TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC50 of 0.6 μM. TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons.

For research use only. We do not sell to patients.

TCID Chemical Structure

TCID Chemical Structure

CAS No. : 30675-13-9

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 65 In-stock
Estimated Time of Arrival: December 31
5 mg USD 59 In-stock
Estimated Time of Arrival: December 31
10 mg USD 94 In-stock
Estimated Time of Arrival: December 31
25 mg USD 215 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC50 of 0.6 μM[1]. TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons[2].

IC50 & Target

IC50: 0.6 μM (UCH-L3) and 75 μM (UCH-L1)[1]

In Vitro

TCID (4,5,6,7-Tetrachloroindan-1,3-dione; compound 11) inhibits UCH-L1 with an IC50 of 75 μM[1].
TCID (10 μM; 1, 2 hours) diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons[2].

Molecular Weight

283.92

Formula

C₉H₂Cl₄O₂

CAS No.

30675-13-9

SMILES

O=C1CC(C2=C1C(Cl)=C(Cl)C(Cl)=C2Cl)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (146.77 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5221 mL 17.6106 mL 35.2212 mL
5 mM 0.7044 mL 3.5221 mL 7.0442 mL
10 mM 0.3522 mL 1.7611 mL 3.5221 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

TCID4,5,6,7-Tetrachloroindan-1,3-dioneDeubiquitinaseDUBsNeuronalubiquitinC-terminalhydrolaseUCH-L3UCH-L1glycinetransporterGlyT2ubiquitinationInhibitorinhibitorinhibit

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TCID
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