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THI0019 

Cat. No.: HY-117388 Purity: >98.0%
Handling Instructions

THI0019 is a potent integrin α4β1 (VLA-4) agonist with an EC50 range of 1-2 μM. THI0019 induces stem/progenitor cells adhesion. THI0019 also regulates adhesion mediated by α4β7, α5β1 and αLβ2.

For research use only. We do not sell to patients.

THI0019 Chemical Structure

THI0019 Chemical Structure

CAS No. : 1378532-99-0

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5 mg USD 580 In-stock
Estimated Time of Arrival: December 31
10 mg USD 950 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

THI0019 is a potent integrin α4β1 (VLA-4) agonist with an EC50 range of 1-2 μM. THI0019 induces stem/progenitor cells adhesion. THI0019 also regulates adhesion mediated by α4β7, α5β1 and αLβ2[1].

IC50 & Target[1]

α4β1

1-2 μM (EC50)

In Vitro

In cell adhesion assays in which Jurkat cells bound to CS1-conjugated BSA, THI0019 shows a dose-dependent enhancement in cell binding with an EC50 of 1.7 μM. When VCAM-1 is used as the ligand, THI0019 induces an even more pronounced 100-fold increase in Jurkat cell binding, with an EC50 of 1.2 μM. THI0019 induces a dose-dependent increase in EPC binding to VCAM-1 (EC50 of 3.7 μM). THI0019 facilitates the rolling and spreading of cells on VCAM-1 and the migration of cells toward SDF-1α[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

601.73

Formula

C₂₉H₃₅N₃O₇S₂

CAS No.

1378532-99-0

SMILES

O=C(N[[email protected]@H](CCCC)COC(N(CC1=CC=CS1)CC2=CC=CS2)=O)N[[email protected]](C3=CC=C4C(OCO4)=C3)CC(OC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: >98.0%

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Keywords:

THI0019THI 0019THI-0019Integrinα4β1VLA-4stemcellα4β7α5β1αLβ2progenitoradhesion,Inhibitorinhibitorinhibit

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THI0019
Cat. No.:
HY-117388
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