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  3. THI0019

THI0019 

Cat. No.: HY-117388 Purity: ≥98.0%
Handling Instructions

THI0019 is a potent integrin α4β1 (VLA-4) agonist with an EC50 range of 1-2 μM. THI0019 induces stem/progenitor cells adhesion. THI0019 also regulates adhesion mediated by α4β7, α5β1 and αLβ2.

For research use only. We do not sell to patients.

THI0019 Chemical Structure

THI0019 Chemical Structure

CAS No. : 1378532-99-0

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5 mg USD 580 Ask For Quote & Lead Time
10 mg USD 950 Ask For Quote & Lead Time

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Description

THI0019 is a potent integrin α4β1 (VLA-4) agonist with an EC50 range of 1-2 μM. THI0019 induces stem/progenitor cells adhesion. THI0019 also regulates adhesion mediated by α4β7, α5β1 and αLβ2[1].

IC50 & Target[1]

α4β1

1-2 μM (EC50)

In Vitro

In cell adhesion assays in which Jurkat cells bound to CS1-conjugated BSA, THI0019 shows a dose-dependent enhancement in cell binding with an EC50 of 1.7 μM. When VCAM-1 is used as the ligand, THI0019 induces an even more pronounced 100-fold increase in Jurkat cell binding, with an EC50 of 1.2 μM. THI0019 induces a dose-dependent increase in EPC binding to VCAM-1 (EC50 of 3.7 μM). THI0019 facilitates the rolling and spreading of cells on VCAM-1 and the migration of cells toward SDF-1α[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

601.73

Formula

C₂₉H₃₅N₃O₇S₂

CAS No.

1378532-99-0

SMILES

O=C(N[[email protected]@H](CCCC)COC(N(CC1=CC=CS1)CC2=CC=CS2)=O)N[[email protected]](C3=CC=C4C(OCO4)=C3)CC(OC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (415.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6619 mL 8.3094 mL 16.6187 mL
5 mM 0.3324 mL 1.6619 mL 3.3238 mL
10 mM 0.1662 mL 0.8309 mL 1.6619 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.46 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (3.46 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.46 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: ≥98.0%

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Keywords:

THI0019THI 0019THI-0019Integrinα4β1VLA-4stemcellα4β7α5β1αLβ2progenitoradhesion,Inhibitorinhibitorinhibit

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THI0019
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HY-117388
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