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TREM2 agonist-2 

Cat. No.: HY-148095
Handling Instructions

TREM2 agonist-2 (I-192) is an orally active triggering receptor expressed on myeloid cells 2 (TREM2) agonist (EC50<0.05 μM).

For research use only. We do not sell to patients.

TREM2 agonist-2 Chemical Structure

TREM2 agonist-2 Chemical Structure

CAS No. : 2738485-98-6

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Description

TREM2 agonist-2 (I-192) is an orally active triggering receptor expressed on myeloid cells 2 (TREM2) agonist (EC50<0.05 μM)[1].

In Vitro

TREM2 agonist-2 (0-100 μM; 16 h) treatment activates hTREM2 in HEK293 cell[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HEK293 cells
Concentration: 0-100 μM
Incubation Time: 16 hours
Result: Showed an EC50 value <0.05 μM.
In Vivo

TREM2 agonist-2 (oral gavage; 50 mg/kg; twice daily; one day) finds TREM2 target engagement on microglia[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Transgenic mice knock-in hTREM2-CV[1]
Dosage: 50 mg/kg
Administration: Oral gavage; 50 mg/kg; twice daily; one day
Result: Increased genes associated with the adaptive immune response, innate immune response, microglia function, cytokine signalling, and cell cycle in hippocampus from animals.
Molecular Weight

451.92

Formula

C24H23ClFN5O

CAS No.
SMILES

CC1=NC2=C(N=C1C)C=C([[email protected]@H]3C[[email protected]](C4=CN(N=C4)C)OCC3)N=C2C5=C(C=C(C=C5)Cl)F

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
TREM2 agonist-2
Cat. No.:
HY-148095
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