2. Apoptosis Stem Cell/Wnt JAK/STAT Signaling Metabolic Enzyme/Protease
  3. Apoptosis STAT MMP
  4. Trigothysoid N

Trigothysoid N is a daphnane diterpenoid with anticancer activity. Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria, regulating the STAT3/FAK signal pathway, and suppressing angiogenesis. Trigothysoid N also induce apoptosis, can be used for research of non-small cell lung cancer (NSCLC).

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Trigothysoid N Chemical Structure

Trigothysoid N Chemical Structure

CAS No. : 1501943-08-3

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Trigothysoid N Related Antibodies

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Description

Trigothysoid N is a daphnane diterpenoid with anticancer activity. Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria, regulating the STAT3/FAK signal pathway, and suppressing angiogenesis. Trigothysoid N also induce apoptosis, can be used for research of non-small cell lung cancer (NSCLC)[1].

In Vitro

Trigothysoid N (5, 15, and 45 μM; 48 h) suppresses tumor cell growth in a dose-dependent manner[1].
Trigothysoid N (5, 10, and 20 μM; 48 h) induces apoptosis and arrests the cell cycle at G0/G1 phase[1].
Trigothysoid N (5, 10, and 20 μM; 48 h) induces MMP depolarization, and increased cellular ROS production, to stimulate A549 cell apoptosis[1].
Trigothysoid N induces apoptosis by mitochondria-dependent signaling, and inhibits A549 cell metastasis via regulating FAK signal pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trigothysoid N Related Antibodies

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 5, 10, and 20 μM
Incubation Time: 48 h
Result: Resulted the apoptotic cell percentages increased from 9.9% (control) to 12.6% (5.0 μM), 15.4% (10.0 μM), and 59.0% (20.0 μM).
In Vivo

Trigothysoid N (0.025, 0.05, and 0.1 μM; 4 h) shows antiangiogenetic activity and antitumor activity against A549 in a transgenic zebrafish model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Transgenic zebrafish model transplanted with CM-DiI-stained A549 cells[1]
Dosage: 0.025, 0.05, and 0.1 μM
Administration:
Result: Inhibited angiogenesis. Disrupted intersegmental blood vessels (ISVs) and dorsal longitudinal anastomotic vessels (DLAVs) in zebrafish.
Inhibited tumor cell proliferation with inhibitory rates of 5.7% (0.025 μM), 14.8% (0.05 μM) and 56.9% (0.1 μM), respectively.
Molecular Weight

794.92

Formula

C44H58O13
CAS No.
SMILES

C[C@H]1[C@@]23[C@@]4([H])C5([H])[C@](O5)([C@H]([C@]6([C@@]2([H])C[C@@H]([C@]6([H])OC(C=CC=C[C@@H]([C@]7([H])[C@H]([C@@](CC7)([H])C[C@@](O)([C@]8(C4([H])O[C@@](OC18[H])(C9=CC=CC=C9)O3)O)C)C)OC(CC(C)C)=O)=O)C)O)O)CO
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
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Trigothysoid N Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trigothysoid N1501943-08-3ApoptosisSTATMMPMatrix metalloproteinasesMitochondriatransgenic zebrafish modelantiangiogenetic activityantitumor activityMMP depolarizationInhibitorinhibitorinhibit

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