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tyk2-in-13

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-144087
    TYK2-IN-11

    		JAK Inflammation/Immunology
    TYK2-IN-11 (Compound 5B) is a selective Tyk-2 inhibitor with IC50s of 0.016 and 0.31 nM for TYK2-JH2 and JAK1-JH2, respectively. TYK2-IN-11 can be used for the research of inflammatory or autoimmune disease .
    <em>TYK2-IN-11</em>
  • HY-150720
    TYK2-IN-12

    		JAK IFNAR Inflammation/Immunology
    TYK2-IN-12 (compound 30) is an orally active, potent and selective TYK2 (tyrosine kinase 2) inhibitor, with a Ki of 0.51 nM. TYK2-IN-12 inhibits IL-12 induced IFNγ, with IC50 values of 2.7 and 7.0 μM in human and mouse whole blood, respectively. TYK2-IN-12 can be used for psoriasis research .
    <em>TYK2-IN-12</em>
  • HY-156961
    Tyk2-IN-14

    		JAK Inflammation/Immunology
    Tyk2-IN-14 is a small molecule inhibitor of TYK2. Tyk2-IN-14 plays an important role in inflammatory diseases and/or diseases associated with hypersecretion of IFNa and/or interferons .
    <em>Tyk2-IN-14</em>
  • HY-163303
    Tyk2-IN-15

    		JAK Inflammation/Immunology
    Tyk2-in-15 (Compound 97) is a selective tyrosine kinase 2 (Tyk2) inhibitor with IC50 value ≤ 10 nM for Tyk2-JH2. Tyk2-IN-15 can be used in the study of inflammatory or autoimmune diseases .
    <em>Tyk2-IN-15</em>
  • HY-163304
    Tyk2-IN-16

    		JAK Cancer
    Tyk2-IN-16 is a selective and potent TYK2 inhibitor with an IC50 of <10 nM for TYK2-JH2. Tyk2-IN-16 inhibits pSTAT4 with an IC50 of <10 nM in NK92 cells (WO2023220046A1; compound 184) .
    <em>Tyk2-IN-16</em>
  • HY-163305
    Tyk2-IN-17

    		JAK Inflammation/Immunology
    Tyk2-IN-17 (compound 185) is a potent TYK2 inhibitor .
    <em>Tyk2-IN-17</em>
  • HY-18709
    Tyk2-IN-3

    Tyk2-IN-3 is a Tyk2 pseudokinase inhibitor, with an IC50 of 485 nM.
    <em>Tyk2-IN-3</em>

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