1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. Tyk2-IN-8

Tyk2-IN-8 

Cat. No.: HY-126290
Handling Instructions

Tyk2-IN-8 (compound 10) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis.

For research use only. We do not sell to patients.

Tyk2-IN-8 Chemical Structure

Tyk2-IN-8 Chemical Structure

CAS No. : 2127109-84-4

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Description

Tyk2-IN-8 (compound 10) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis[1].

IC50 & Target

IC50: 17 nM (TYK2 JH1)[1]

In Vitro

Tyk2-IN-8 also inhibits JAK1 (IC50=74 nM) and JAK2 (IC50=383 nM)[1].

Molecular Weight

383.41

Formula

C₂₀H₁₇N₉

CAS No.

2127109-84-4

SMILES

N#CC[[email protected]@]1(N2N=CC(C3=NC(C4=CN(C)N=C4)=CN5C3=CC=N5)=C2)C[[email protected]](C#N)C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Tyk2-IN-8
Cat. No.:
HY-126290
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