1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. Tyk2-IN-9

Tyk2-IN-9 

Cat. No.: HY-126290A Purity: 99.62%
Handling Instructions

Tyk2-IN-9 is a potent,selective and specific inhibitor of JAK kinases, inhibits Tyk2, JAK1 and JAK2 with IC50 values of 6 nM, 21nM and 6nM, respectively. Tyk2-IN-9, example 19, is extracted from patent US2017240552A1.

For research use only. We do not sell to patients.

Tyk2-IN-9 Chemical Structure

Tyk2-IN-9 Chemical Structure

CAS No. : 2127109-85-5

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5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 990 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2550 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Tyk2-IN-9 is a potent,selective and specific inhibitor of JAK kinases, inhibits Tyk2, JAK1 and JAK2 with IC50 values of 6 nM, 21nM and 6nM, respectively. Tyk2-IN-9, example 19, is extracted from patent US2017240552A1[1].

IC50 & Target[1]

Tyk2

6 nM (IC50)

JAK1

21 nM (IC50)

JAK2

8 nM (IC50)

In Vitro

Tyk2-IN-9 has the ability to inhibit IL-12 signaling in a human whole blood with an IC50 value of 28 nM in a flow cytometry assay[1].

Molecular Weight

383.41

Formula

C₂₀H₁₇N₉

CAS No.

2127109-85-5

SMILES

N#CC[[email protected]@]1(N2N=CC(C3=NC(C4=CN(C)N=C4)=CN5C3=CC=N5)=C2)C[[email protected]](C#N)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 3.33 mg/mL (8.69 mM; ultrasonic and adjust pH to 4 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6082 mL 13.0409 mL 26.0817 mL
5 mM 0.5216 mL 2.6082 mL 5.2163 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Tyk2-IN-9JAKJanus kinaseTyk2JAK1JAK2il-12Inhibitorinhibitorinhibit

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Tyk2-IN-9
Cat. No.:
HY-126290A
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