1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. UB-165 fumarate

UB-165 fumarate 

Cat. No.: HY-107688A
Handling Instructions

UB-165 fumarate is a nAChR agonist, being a full agonist of the α3β2 isoform and a partial agonist of the α4β2* isoform, with a Ki value of 0.27 nM for nicotine binding in rat brain.

For research use only. We do not sell to patients.

UB-165 fumarate Chemical Structure

UB-165 fumarate Chemical Structure

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Description

UB-165 fumarate is a nAChR agonist, being a full agonist of the α3β2 isoform and a partial agonist of the α4β2* isoform, with a Ki value of 0.27 nM for nicotine binding in rat brain[1].

IC50 & Target

Ki: 0.27 nM (nicotine in rat brain)[1].

In Vitro

UB-165 stimulates [3H]-dopamine release from striatal synaptosomes with EC50 values of 2.4, 134, and 88 nM, and relative efficacies of 1:0.4:0.2, respectively[1].

Molecular Weight

350.80

Formula

C₁₇H₁₉ClN₂O₄

SMILES

ClC1=NC=C(C2=CCC[[email protected]@]3([H])N[[email protected]]2([H])CC3)C=C1.O=C(O)/C=C/C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

UB-165UB165UB 165nAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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UB-165 fumarate
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HY-107688A
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