Ubiquitination-IN-2 

Ubiquitination-IN-2 is a potent E1-E2 protein−protein interactions (PPI) inhibitor. Ubiquitination-IN-2 has a K_d value of 0.72 μM for ubiquitin E1 (Uba1). Ubiquitination-IN-2 inhibits blocks ubiquitin transfer from E1 to E2. Ubiquitination-IN-2 can be used in research of cancer^[1].

Ubiquitination-IN-2 (M1-S1; 0-50 μM; 16 h; HEK293T cells) inhibits ubiquitin transfer to substrate protein CDK4 by blocking its monoubiquitination catalyzed by CHIP^[1].
Ubiquitination-IN-2 (0-50 μM; HEK293T cells) inhibits the protein ubiquitination cascade by binding with Uba1, the E1 enzyme, and blocking ubiquitin transfer from E1 to E2^[1].
Ubiquitination-IN-2 (0-50 μM; HEK293T cells) inhibits ubiquitin transfer to different types of E2 enzymes and inhibits the formation of E2-UB conjugates at 50 μM concentration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2346.04

C₉₃H₁₇₃N₂₅O₂₈S₈

O=C(CN(C[C@H](NC(CN(C[C@@H](NC(CN(C[C@H](NC(C)=O)CCCCN)S(=O)(C1=CC=C(C=C1)OC)=O)=O)CCCCNC2=O)S(=O)(C)=O)=O)CCCCN)S(=O)(CCN)=O)N[C@@H](CN(CC(N[C@@H](CN(CC(N[C@@H](CN(CC(N[C@@H](CN(CC(N[C@@H](CN(CC(N)=O)S(=O)(CCN)=O)CC(C)C)=O)S(=O)(C)=O)CCCCN)=O)S(=O)(CC(C)C)=O)CC(C)C)=O)S(=O)(C)=O)CCCCN)=O)S(=O)(C)=O)CCCCNC(C3=CC=C2C=C3)=O

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• [1]. Zhou L, et, al. Inhibition of the Ubiquitin Transfer Cascade by a Peptidomimetic Foldamer Mimicking the E2 N-Terminal Helix. J Med Chem. 2023 Jan 12;66(1):491-502.  [Content Brief]