1. Cell Cycle/DNA Damage
    Apoptosis
    Autophagy
  2. Topoisomerase
    Caspase
    Ferroptosis
    Autophagy
  3. Ungeremine

Ungeremine 

Cat. No.: HY-N1971
Handling Instructions

Ungeremine, a phenanthridine type alkaloid, is extracted of the bulbs of Pancratium Illyricum. Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. Ungeremine displays cytotoxic activity towards the 9 cancer cell lines, including drug-sensitive and MDR phenotypes. Ungeremine induced ferroptosis, necroptosis, autophagy as well as apoptosis mediated by caspase activation, MMP alteration and increase ROS production.

For research use only. We do not sell to patients.

Ungeremine Chemical Structure

Ungeremine Chemical Structure

CAS No. : 2121-12-2

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Description

Ungeremine, a phenanthridine type alkaloid, is extracted of the bulbs of Pancratium Illyricum. Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. Ungeremine displays cytotoxic activity towards the 9 cancer cell lines, including drug-sensitive and MDR phenotypes. Ungeremine induced ferroptosis, necroptosis, autophagy as well as apoptosis mediated by caspase activation, MMP alteration and increase ROS production[1][2].

Molecular Weight

266.27

Formula

C₁₆H₁₂NO₃

CAS No.

2121-12-2

SMILES

OC1=CC2=C([N+]3=CC4=CC5=C(OCO5)C=C42)C(CC3)=C1

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

UngeremineTopoisomeraseCaspaseFerroptosisAutophagyalkaloidcytotoxiccancercellsferroptosisROSMDRphenotypesInhibitorinhibitorinhibit

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