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UPF 1069 Chemical Structure
|Product name: UPF 1069|
|Cat. No.: HY-14478|
UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM; ~27-fold selective against PARP1.
IC50 Value: 0.3 μM
in vitro: In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 micromolxL(-1)) caused a concentration-dependent exacerbation (up to 155%) of OGD-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, had no effect on OGD injury .
in vivo: In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage.
Clinical trial: N/A
|M.Wt||279.29||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
100 mM in DMSO
|1 mg||5 mg||10 mg|
|1 mM||3.5805 mL||17.9025 mL||35.8051 mL|
|5 mM||0.7161 mL||3.5805 mL||7.1610 mL|
|10 mM||0.3581 mL||1.7903 mL||3.5805 mL|
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