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V-9302 hydrochloride 

Cat. No.: HY-112683A Purity: 98.13%
Handling Instructions

V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. V-9302 hydrochloride selectively and potently targets the amino acid transporter ASCT2 (SLC1A5). V-9302 hydrochloride inhibits ASCT2-mediated glutamine uptake (IC50=9.6 µM) in HEK-293 cells.

For research use only. We do not sell to patients.

V-9302 hydrochloride Chemical Structure

V-9302 hydrochloride Chemical Structure

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 114 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 285 In-stock
Estimated Time of Arrival: December 31
50 mg USD 510 In-stock
Estimated Time of Arrival: December 31
100 mg USD 850 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. V-9302 hydrochloride selectively and potently targets the amino acid transporter ASCT2 (SLC1A5). V-9302 hydrochloride inhibits ASCT2-mediated glutamine uptake (IC50=9.6 µM) in HEK-293 cells[1].

IC50 & Target

ASCT2[1]

In Vitro

V-9302 hydrochloride inhibits ASCT2-mediated glutamine uptake in human cells in a concentration-dependent fashion and exhibits a 100-fold improvement in potency over gamma-L-glutamyl-p-nitroanilide[1].
Pharmacological blockade of ASCT2 with V-9302 hydrochloride results in attenuated cancer cell growth and proliferation, increases cell death, and increases oxidative stress[1].

In Vivo

V-9302 hydrochloride (75 mg/kg; i.p.; daily fo 21 days) prevents tumor growth in both HCT-116and HT29 xenograft models[1].

Animal Model: 6-week old, female athymic nude mice (bearing HCT-116 (KRASG13D) or HT29 (BRAFV600E) cell-line )[1]
Dosage: 75 mg/kg
Administration: Intraperitoneally; daily fo 21 days
Result: Prevented tumor growth.
Molecular Weight

575.14

Formula

C₃₄H₃₉ClN₂O₄

SMILES

O=C(O)[[email protected]@H](N)CCN(CC1=CC=CC=C1OCC2=CC=CC(C)=C2)CC3=CC=CC=C3OCC4=CC=CC(C)=C4.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (434.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7387 mL 8.6935 mL 17.3871 mL
5 mM 0.3477 mL 1.7387 mL 3.4774 mL
10 mM 0.1739 mL 0.8694 mL 1.7387 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

V-9302V9302V 9302OthersglutamineuptakefluxtransporterproliferationoxidativestressathymicnudemiceHEK-293Inhibitorinhibitorinhibit

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Product Name:
V-9302 hydrochloride
Cat. No.:
HY-112683A
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