1. Cell Cycle/DNA Damage
    Neuronal Signaling
    GPCR/G Protein
    Metabolic Enzyme/Protease
  2. PPAR
    Cannabinoid Receptor
    HIF/HIF Prolyl-Hydroxylase
  3. VCE-​004.8

VCE-​004.8 

Cat. No.: HY-128872
Handling Instructions

VCE-004.8, a semi-synthetic multitarget cannabinoquinoid, is a specific PPARγ and CB2 receptor dual agonist with potent anti-inflammatory activity. VCE-004.8 inhibits prolyl-hydroxylases (PHDs) and activates the HIF pathway. VCE-004.8 attenuates adipogenesis and prevents diet-induced obesity.

For research use only. We do not sell to patients.

VCE-​004.8 Chemical Structure

VCE-​004.8 Chemical Structure

CAS No. : 1818428-24-8

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Description

VCE-004.8, a semi-synthetic multitarget cannabinoquinoid, is a specific PPARγ and CB2 receptor dual agonist with potent anti-inflammatory activity[1]. VCE-004.8 inhibits prolyl-hydroxylases (PHDs) and activates the HIF pathway. VCE-004.8 attenuates adipogenesis and prevents diet-induced obesity[2].

IC50 & Target[1]

PPARγ

 

CB2

 

In Vivo

VCE-004.8 ( injection; 20 mg/kg/day; for 3 weeks) induces a significant reduction in body weight gain, total fat mass, adipocyte volume and plasma triglycerides levels in HFD mice. VCE-004.8 can also significantly ameliorate glucose tolerance, reduce leptin levels (a marker of adiposity) and increase adiponectin and incretins (GLP-1 and GIP) levels[1].

Molecular Weight

433.58

Formula

C₂₈H₃₅NO₃

CAS No.

1818428-24-8

SMILES

O=C1C(O)=C([[email protected]@H]2C=C(C)CC[[email protected]]2C(C)=C)C(C(NCC3=CC=CC=C3)=C1CCCCC)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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VCE-​004.8
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