1. Cell Cycle/DNA Damage
    Epigenetics
    Apoptosis
  2. PARP
    MDM-2/p53
  3. Verminoside

Verminoside 

Cat. No.: HY-N1094
Handling Instructions

Verminoside is an iridoid isolated from Kigelia africana, exhibits anti-inflammatory and remarkable antioxidant activity with a radical-scavenging activity of 2.5 μg/mL. The genotoxicity of Verminoside on human lymphocytes is associated with elevated levels of PARP-1 and p53 proteins.

For research use only. We do not sell to patients.

Verminoside Chemical Structure

Verminoside Chemical Structure

CAS No. : 50932-19-9

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Description

Verminoside is an iridoid isolated from Kigelia africana, exhibits anti-inflammatory and remarkable antioxidant activity with a radical-scavenging activity of 2.5 μg/mL. The genotoxicity of Verminoside on human lymphocytes is associated with elevated levels of PARP-1 and p53 proteins[1][2][3].

IC50 & Target[2]

PARP-1

 

In Vitro

Verminoside (Compound 1; 0.01-1 mM; 25 hours; J774.A1 macrophages) treatment shows significant and concentration-related inhibition of iNOS expression at 0.1 mM and 1 mM in LPS-stimulated J774.A1 macrophages[1].

Western Blot Analysis[1]

Cell Line: J774.A1 macrophages
Concentration: 0.01 mM, 0.1 mM or 1 mM
Incubation Time: 25 hours
Result: Showed significant and concentration-related inhibition of iNOS expression at 0.1 mM and 1 mM in LPS-stimulated J774.A1 macrophages.
Molecular Weight

524.47

Formula

C₂₄H₂₈O₁₃

CAS No.

50932-19-9

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

VerminosidePARPMDM-2/p53poly ADP ribose polymeraseInhibitorinhibitorinhibit

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