1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
  3. Vinflunine ditartrate

Vinflunine ditartrate 

Cat. No.: HY-B0628B Purity: ≥95.0%
Handling Instructions

Vinflunine ditartrate is the first fluorinated microtubule inhibitor belonging to the Vinca alkaloids family. Vinflunine ditartrate has anti-angiogenic, vascular-disrupting and anti-metastatic activities. Vinflunine ditartrate can be used for the research of transitional cell carcinoma of the urothelial tract, non-small cell lung cancer, and carcinoma of the breast.

For research use only. We do not sell to patients.

Vinflunine ditartrate Chemical Structure

Vinflunine ditartrate Chemical Structure

CAS No. : 194468-36-5

Size Price Stock Quantity
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Vinflunine ditartrate is the first fluorinated microtubule inhibitor belonging to the Vinca alkaloids family. Vinflunine ditartrate has anti-angiogenic, vascular-disrupting and anti-metastatic activities. Vinflunine ditartrate can be used for the research of transitional cell carcinoma of the urothelial tract, non-small cell lung cancer, and carcinoma of the breast[1][2].

IC50 & Target

microtubule[1]

In Vitro

Vinflunine (0.01-10 μM; 45 min) induces a rapid change in endothelial cell shape: cells retracted and assumed a rounded morphology[2].
Vinflunine (0.01-10 μM; 1 h) disrupts newly formed capillary-like structures[2].
Vinflunine (0.01-10 μM; 1 h) inhibits endothelial cell motility, with an IC50 of 0.71 μM[2].
Vinflunine (0.001-10 μM; 1-72 h) inhibits endothelial cell proliferation in vitro[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Vinflunine (0.08-20 mg/kg; i.v.) reduces the number of experimental liver metastases by human LS174T colon cancer cells[2].
Vinflunine (0.63-5 mg/kg; i.v. before and 2 d after Matrigel implantation) inhibits the bFGF-induced angiogenic response in mice in a dose-dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice (BALB/c/Ola/Hsd-nu) were implanted LS174T cells[2]
Dosage: 0.08, 0.16, 1.25, 5, 10, 20 mg/kg
Administration: I.v. on days 4, 7, 11, 14, 18 and 21 after tumour cell implantation
Result: Induced a dose-dependent reduction in the number of metastatic foci at the surface of the liver and was well tolerated.
Clinical Trial
Molecular Weight

1117.10

Formula

C₅₃H₆₆F₂N₄O₂₀

CAS No.

194468-36-5

SMILES

OC([[email protected]](O)[[email protected]@H](O)C(O)=O)=O.OC([[email protected]](O)[[email protected]@H](O)C(O)=O)=O.CC[[email protected]@]1(C=CCN2CC3)[[email protected]@]2([H])[[email protected]@]3(C(C=C([[email protected]](C4=C5C(C=CC=C6)=C6N4)(CC(C[[email protected]@H](C(F)(F)C)C7)([H])CN7C5)C(OC)=O)C(OC)=C8)=C8N9C)[[email protected]]9([H])[[email protected]](C(OC)=O)(O)[[email protected]@H]1OC(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: ≥95.0%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Vinflunine ditartrateMicrotubule/TubulinmicrotubuleVincaalkaloidsanti-angiogenicvascular-disruptinganti-metastatictransitionalcarcinomaurothelialtractnon-smalllungcancerbreastInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Vinflunine ditartrate
Cat. No.:
HY-B0628B
Quantity:
MCE Japan Authorized Agent: