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Signaling Pathway

Vinflunine

HY-B0628

Vinflunine

Vinflunine Chemical Structure

Vinflunine is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity.

Vinflunine

CAS No.: 162652-95-1 Backordered

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5 mg $156 Backordered
10 mg $258 Backordered
50 mg $860 Backordered
100 mg $1580 Backordered

Vinflunine Tartrate

CAS No.: 1201898-17-0 In-stock

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Product name: Vinflunine
Cat. No.: HY-B0628

Vinflunine Data Sheet

  • Network Version

    DataSheet

Related Compound Libraries

Biological Activity of Vinflunine

Vinflunine is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity.
Target: Microtubule/Tubulin
The major effects of Vinflunine on dynamic instability are a slowing of the microtubule growth rate, an increase in growth duration, and a reduction in shortening duration. The effects of Vinflunine on the readmilling rate is examined by following [3H]GTP incorporation into MAP-rich microtubules, and the IC50 is 0.42 μM [1]. Vinflunine induced mitotic accumulation with IC50 with 18.8 nM, which decreases the centromere dynamicity by 44% and increases the time centromeres spent ina paused state by 63% [2]. Treatment of Vinflunine induces a rapid change in endothelial cell shape: cells retracts and assumes a rounded morphology. Mean IC50 values are 9.9 × 10-5 M × 10-5 M for fibronectin and 5.0× 10-5 M × 10-5 M for type IV collagen. A short 4 hours exposure of endothelial cells to Vinflunine at 10-8</SUP-10-4 M results in an inhibition of endothelial cell motility response to NIH3T3 cells-derived angiogenic factors. Inhibition is dose dependent, with a mean IC50 value of 7.1 × 10-7 × 10-7 M [3].
Intravenous treatment of mice with Vinflunine, immediately before and 2 day after Matrigel implantation, results in a dose-dependent inhibition of the bFGF-induced angiogenic response, compared with vehicle-treated animals. Inhibition of haemoglobin content is significant at 1.25, 2.5 and 5 mg/kg, with no effect at 0.63 mg/kg (P > 0.05). An ID50 value (dose which inhibits 50% of bFGF-induced neovascularisation) is calculated as 1 mg/kg. Low doses of Vinflunine reduce the number of experimental liver metastases by human LS174T colon cancer cell. A slight overall decrease in liver metastatic foci is already observed at the very low dose of 0.16 mg/kg Vinflunine, although maximal overall inhibition is reached at the maximal tolerated dose (MTD) of 20 mg/kg [3].
 

Chemical Information

M.Wt 816.93 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₄₅H₅₄F₂N₄O₈
CAS No 162652-95-1
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.2241 mL 6.1205 mL 12.2410 mL
5 mM 0.2448 mL 1.2241 mL 2.4482 mL
10 mM 0.1224 mL 0.6120 mL 1.2241 mL

References on Vinflunine

Inhibitor Kit

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