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Glycomimetic Library

Cat. No.: HY-L0079V

A specially synthesized set of 2,470 compounds able to mimic glycosides and their interaction with proteins. The main emphasis of library design was made on drug-like compounds enriched with H-bond donors (possess at least two H-bond donors) and bearing nature-like Fsp3–rich scaffolds with diverse spatial orientation of H-bond donors and different 3D-shapes.

Glycomimetic Library
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100 μL/well (10 mM solution) Get quote In-stock

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•   A specially synthesized set of 2,470 compounds able to mimic glycosides and their interaction with proteins.

•   Privileged core fragments and side chain functionalities: cyclic amino alcohols, cyclic glycols; O,N-containing aliphatic rings; polyalcohols.

•   We suppose the library application would identify new attractive chemotypes which correspond to drug-/lead-like criteria and on the other hand participate in key interactions similar to glycoside binding in the active site of the targets.

•   Nature-likeness scoring algorithm: Taverna 2.5 workbench, similarity to available NP databases.

•   MedChem structural filters, removal of common and trivial chemotypes: PAINS, REOS, Elli Lily rules and strict Enamine filters.

•   Structurally diverse.

•   NMR and HPLC validated to ensure high purity and quality.

•   All compounds can be readily followed with analogues either from stock or from new syntheses.

•   Databases and compounds are provided by Enamine.

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Glycomimetic Library
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