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  3. VNRX-5133

VNRX-5133 

Cat. No.: HY-120065
Handling Instructions

VNRX-5133 is a cyclic boronate β-lactamase inhibitor. VNRX-5133 has direct inhibitory activity against serine-active site β-lactamases (Ser-BL) and metallo-β-lactamases (MBL). VNRX-5133 is highly active against multidrug-resistant (MDR)-K. pneumonia and P. aeruginosa clinical isolates.

For research use only. We do not sell to patients.

VNRX-5133 Chemical Structure

VNRX-5133 Chemical Structure

CAS No. : 1613268-23-7

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Description

VNRX-5133 is a cyclic boronate β-lactamase inhibitor. VNRX-5133 has direct inhibitory activity against serine-active site β-lactamases (Ser-BL) and metallo-β-lactamases (MBL). VNRX-5133 is highly active against multidrug-resistant (MDR)-K. pneumonia and P. aeruginosa clinical isolates[1].

IC50 & Target

β-lactamase[1]

In Vitro

VNRX-5133 is a potent β-lactamase inhibitor (BLI) possessing a unique broad spectrum of activity, including Class A, C, and D Ser-BLs. VNRX-5133 enhances the activity of Cefepime against resistant Enterobacteriaceae and P. aeruginosa isolates in a neutropenic mouse-thigh infection model[1].

Clinical Trial
Molecular Weight

389.25

Formula

C₁₉H₂₈BN₃O₅

CAS No.

1613268-23-7

SMILES

OC(C1=C2C(C[[email protected]@H](NC(C[[email protected]@H]3CC[[email protected]@H](NCCN)CC3)=O)B(O)O2)=CC=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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VNRX-5133
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