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Products are for research use only. Not for human use. We do not sell to patients.
(VX702; VX 702)
VX-702 Chemical Structure
|Product name: VX-702|
|Cat. No.: HY-10401|
VX-702 is a highly selective inhibitor of p38α MAPK(IC50=4 -20 nM), 14-fold higher potency against the p38α versus p38β.
IC50 value: 4-20 nM 
Target: p38α MAPK
in vitro: Pre-incubation of platelets with VX-702 (1 μM) completely or partially inhibits p38 activation (IC50 4 to 20 nM) induced by platelet agonists including thrombin, SFLLRN, AYPGKF, U46619 and collagen. VX-702 shows no effect on platelet aggregation induced by any of the p38 MAPK agonists in the presence or absence of anti-platelet therapies . VX-702 inhibits the production of IL-6, IL-1β and TNFα (IC50 = 59, 122 and 99 ng/mL, respectively) in a dose-dependent manner .
in vivo: The half-life of VX-702 is 16 to 20 hours, with a median clearance of 3.75 L/h and a volume of distribution of 73 L/kg. Both AUC and Cmax values are dose proportional for VX-702, which is predominantly cleared renally . VX-702 (at a dose of 0.1 mg/kg twice daily) has an equivalent effect as that of methotrexate (0.1 mg/kg). In addition, VX-702 (5 mg/kg twice daily) also has an equivalent effect as prednisolone (10 mg/kg once daily), as measured by percentage inhibition of wrist joint erosion and inflammation score .
|M.Wt||404.32||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO: ≥ 42 mg/mL
|1 mg||5 mg||10 mg|
|1 mM||2.4733 mL||12.3664 mL||24.7329 mL|
|5 mM||0.4947 mL||2.4733 mL||4.9466 mL|
|10 mM||0.2473 mL||1.2366 mL||2.4733 mL|
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