1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. WSD0922

WSD0922 

Cat. No.: HY-139299
Handling Instructions

WSD-0922 is a potent, selective, orally active, and BBB penetrable EGFR/EGFRVIII inhibitor. WSD-0922 is against EGFRm+ (EGFRvIII/Del19/L858R) with an IC50 of <10 nM. WSD0922 shows good safety profile and preclinical anti-tumor efficacy.

For research use only. We do not sell to patients.

WSD0922 Chemical Structure

WSD0922 Chemical Structure

CAS No. : 2226552-64-1

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Description

WSD-0922 is a potent, selective, orally active, and BBB penetrable EGFR/EGFRVIII inhibitor. WSD-0922 is against EGFRm+ (EGFRvIII/Del19/L858R) with an IC50 of <10 nM. WSD0922 shows good safety profile and preclinical anti-tumor efficacy[1].

IC50 & Target

IC50: EGFRm+ (EGFRvIII/Del19/L858R)[1]

In Vivo

WSD0922 treatment results in tumor regression on cetuximab resistant PDX model of HNSCC.
WSD0922 demonstrates remarkable tumor regression in 3 PDX models (platinum sensitive/insensitive/EGFRm+). WSD0922 is well tolerated in GLP tox at dose ~10x clinical equivalent dose.[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

442.43

Formula

C₂₃H₂₁F₃N₄O₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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WSD0922
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