1. Anti-infection
  2. Bacterial
    Fungal
  3. XR586

XR586 

Cat. No.: HY-P2359
Handling Instructions

XR586 is a peptaibol-like antibiotic isolated from fermentations of Acremonium persicinum. XR586 contains several alpha-aminoisobutyric acid (Aib) residues, lacks a terminal phenylalaninol and terminates in the sequence Phe-Gly.

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XR586 Chemical Structure

XR586 Chemical Structure

CAS No. : 185981-24-2

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Description

XR586 is a peptaibol-like antibiotic isolated from fermentations of Acremonium persicinum. XR586 contains several alpha-aminoisobutyric acid (Aib) residues, lacks a terminal phenylalaninol and terminates in the sequence Phe-Gly[1].

In Vitro

The mechanism of the anti-bacterial activity and toxicity: XR586 shows many structural and conformational features in common with peptaibols, particularly the zervamicins. Peptaibol antibiotics are peptides, typically of 15-20 residues, containing a large proportion of alpha-aminoisobutyric acid (Aib) residues. These peptides adopt a helical conformation in solution and display anti-bacterial and toxic properties due to their ability to form pores in membranes[1].

Molecular Weight

1864.19

Formula

C₉₁H₁₃₈N₂₀O₂₂

CAS No.

185981-24-2

Sequence Shortening

Ac-W-{Iva}-Q-{Aib}-IT-{Aib}-L-{Aib}-PQ-{Aib}-{Hyp}-{Iva}-PFG

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

XR586XR 586XR-586BacterialFungalantibioticAcremoniumpersicinumInhibitorinhibitorinhibit

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