α-Conotoxin AuIB TFA

Name: α-Conotoxin AuIB TFA
Brand: MedChemExpress
SKU: HY-P1269A
Rating: 4.5 (1 reviews)

Cat. No.: HY-P1269A Purity: 97.37%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

α-Conotoxin AuIB TFA, a potent and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist, blocks α3β4 nAChRs expressed in Xenopus oocytes with an IC₅₀ of 0.75 μM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

α-Conotoxin AuIB TFA Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of α-Conotoxin AuIB TFA:

α-Conotoxin AuIB Get quote

1 Publications Citing Use of MCE α-Conotoxin AuIB TFA

•Acta Pharm Sin B. 2024 Feb 6.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

α-Conotoxin AuIB TFA, a potent and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist, blocks α3β4 nAChRs expressed in Xenopus oocytes with an IC₅₀ of 0.75 μM^[1].

IC₅₀ & Target

IC50: 0.75 μM (α3β4 nAChR; in Xenopus oocytes)^[1]

In Vitro

α-Conotoxin AuIB blocks the α3β4 receptor with >100-fold higher potency than other receptor subunit combinations, including α2β2, α2β4, α3β2, α4β2, α4β4, and α1β1γδ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1686.79

Formula

C₆₇H₉₀F₃N₁₇O₂₃S₄

Appearance

Solid

Color

White to off-white

Sequence

Gly-Cys-Cys-Ser-Tyr-Pro-Pro-Cys-Phe-Ala-Thr-Asn-Pro-Asp-Cys-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys15)

Sequence Shortening

GCCSYPPCFATNPDC-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys15)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (59.28 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.5928 mL	2.9642 mL	5.9284 mL
5 mM	0.1186 mL	0.5928 mL	1.1857 mL
10 mM	0.0593 mL	0.2964 mL	0.5928 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (59.28 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 97.37%

Select Batch:

Data Sheet (281 KB) SDS (252 KB)

COA (260 KB) RP-HPLC (114 KB) MS (243 KB)

Handling Instructions (2659 KB)

References

[1]. Siqin Luo, et al. α-Conotoxin AuIB Selectively Blocks α3β4 Nicotinic Acetylcholine Receptors and Nicotine-Evoked Norepinephrine Release.Journal of Neuroscience. 1998 Nov 1, 18 (21): 8571-8579.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.5928 mL	2.9642 mL	5.9284 mL	14.8211 mL
	5 mM	0.1186 mL	0.5928 mL	1.1857 mL	2.9642 mL
	10 mM	0.0593 mL	0.2964 mL	0.5928 mL	1.4821 mL
	15 mM	0.0395 mL	0.1976 mL	0.3952 mL	0.9881 mL
	20 mM	0.0296 mL	0.1482 mL	0.2964 mL	0.7411 mL
	25 mM	0.0237 mL	0.1186 mL	0.2371 mL	0.5928 mL
	30 mM	0.0198 mL	0.0988 mL	0.1976 mL	0.4940 mL
	40 mM	0.0148 mL	0.0741 mL	0.1482 mL	0.3705 mL
	50 mM	0.0119 mL	0.0593 mL	0.1186 mL	0.2964 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.