α-Conotoxin EI 

α-Conotoxin EI is a selective nicotinic acetylcholine α1β1γδ receptor (nAChR) antagonist (IC₅₀=187 nM) and an α3β4 receptor inhibitor. α-Conotoxin EI can block muscle and ganglionic receptors^[1][2][3].

IC₅₀: 187 nM (nicotinic acetylcholine α1β1γδ receptor)^[3]

α-Conotoxin EI (10 µM) blocks muscle and ganglionic receptors, but less potent for the central nevous system receptor^[3].
α-Conotoxin EI (10 µM) blocks the α1β1γδ receptors with a τon of 4.9 s, and blocks the α3β4 receptor with a τon of 11 s^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Conotoxin EI (intraperitoneal injection) into mice induces muscular weakness, followed by flaccid paralysis and ultimately death^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2093.37

C₈₃H₁₂₅N₂₇O₂₇S₅

170663-33-9

Arg-Asp-{Hyp}-Cys-Cys-Tyr-His-Pro-Thr-Cys-Asn-Met-Ser-Asn-Pro-Gln-Ile-Cys-NH2 (Disulfide bridge:Cys4-Cys10;Cys5-Cys18)

RD-{Hyp}-CCYHPTCNMSNPQIC-NH2 (Disulfide bridge: Cys4-Cys10;Cys5-Cys18)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Martinez JS, et al. alpha-Conotoxin EI, a new nicotinic acetylcholine receptor antagonist with novel selectivity. Biochemistry. 1995 Nov 7;34(44):14519-26.  [Content Brief]

  [2]. Ning J, et al. Identification of Crucial Residues in α-Conotoxin EI Inhibiting Muscle Nicotinic Acetylcholine Receptor. Toxins (Basel). 2019 Oct 16;11(10):603.  [Content Brief]

  [3]. López-Vera E, et al. Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS J. 2007 Aug;274(15):3972-85.  [Content Brief]