1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. nAChR
  3. α-Conotoxin Im-I

α-Conotoxin Im-I is a selective α7/α9 nAChR antagonist, blocking α7 nicotinic receptors with the highest apparent affinity, while having an 8-fold lower affinity for homomeric α9 nicotinic receptors. α-Conotoxin Im-I is toxic and induces seizures in rodents. α-Conotoxin Im-I is a tool for studying neuronal nAChR.

For research use only. We do not sell to patients.

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α-Conotoxin Im-I Chemical Structure

α-Conotoxin Im-I Chemical Structure

CAS No. : 156467-85-5

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Description

α-Conotoxin Im-I is a selective α7/α9 nAChR antagonist, blocking α7 nicotinic receptors with the highest apparent affinity, while having an 8-fold lower affinity for homomeric α9 nicotinic receptors. α-Conotoxin Im-I is toxic and induces seizures in rodents. α-Conotoxin Im-I is a tool for studying neuronal nAChR[1][2].

IC50 & Target

α7/α9 nAChR[1][2].

Molecular Weight

1351.56

Formula

C52H78N20O15S4

CAS No.
Sequence Shortening

Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Ala-Trp-Arg-Cys-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys12)

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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α-Conotoxin Im-I Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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α-Conotoxin Im-I
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