2. Anti-infection
  3. HSV
  4. 1-Docosanol

1-Docosanol  (Synonyms: Behenyl alcohol)

Cat. No.: HY-B0222 Purity: ≥98.0%
COA Handling Instructions

Molarity Calculator

1-Docosanol (Behenyl alcohol) is a saturated fatty alcohol with reported inhibitory activity against lipid-enveloped viruses, including herpes simplex virus (HSV).

For research use only. We do not sell to patients.

1-Docosanol Chemical Structure

1-Docosanol Chemical Structure

CAS No. : 661-19-8

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Based on 1 publication(s) in Google Scholar

Other Forms of 1-Docosanol:

1-Docosanol Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE 1-Docosanol

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

1-Docosanol (Behenyl alcohol) is a saturated fatty alcohol with reported inhibitory activity against lipid-enveloped viruses, including herpes simplex virus (HSV)[1][2].

In Vitro

1-Docosanol (0-5 mg/mL, 24 h) inhibits replication of wild-type and Acyclovir (HY-17422)-resistant HSV in Vero cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1-Docosanol Related Antibodies
In Vivo

1-Docosanol (0-1000 mg/kg, oral gavage, 26 weeks) shows no adverse effects in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

326.60

Formula

C22H46O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCCCCCCCCO
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

Ethanol : 50 mg/mL (153.09 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0618 mL 15.3092 mL 30.6185 mL
5 mM 0.6124 mL 3.0618 mL 6.1237 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% EtOH    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.65 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 3.0618 mL 15.3092 mL 30.6185 mL 76.5462 mL
5 mM 0.6124 mL 3.0618 mL 6.1237 mL 15.3092 mL
10 mM 0.3062 mL 1.5309 mL 3.0618 mL 7.6546 mL
15 mM 0.2041 mL 1.0206 mL 2.0412 mL 5.1031 mL
20 mM 0.1531 mL 0.7655 mL 1.5309 mL 3.8273 mL
25 mM 0.1225 mL 0.6124 mL 1.2247 mL 3.0618 mL
30 mM 0.1021 mL 0.5103 mL 1.0206 mL 2.5515 mL
40 mM 0.0765 mL 0.3827 mL 0.7655 mL 1.9137 mL
50 mM 0.0612 mL 0.3062 mL 0.6124 mL 1.5309 mL
60 mM 0.0510 mL 0.2552 mL 0.5103 mL 1.2758 mL
80 mM 0.0383 mL 0.1914 mL 0.3827 mL 0.9568 mL
100 mM 0.0306 mL 0.1531 mL 0.3062 mL 0.7655 mL
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1-Docosanol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Docosanol661-19-8Behenyl alcoholHSVHerpes simplex virusVeroAcyclovirInhibitorinhibitorinhibit

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