12R-LOX-IN-2

Cat. No.: HY-155244 Purity: 99.85%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

12R-LOX-IN-2 (compound 7b) is an inhibitor of 12R-lipoxygenase (12R-LOX). 12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and suppresses colony formation. 12R-LOX-IN-2 also reduced the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 can be used in research into psoriasis and other skin-related inflammatory diseases.

For research use only. We do not sell to patients.

12R-LOX-IN-2 Chemical Structure

CAS No. : 3026677-37-9

Size	Price	Stock	Quantity
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 400	Get quote	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

12R-lipoxygenase (12R-LOX)^[1]

Molecular Weight

271.31

Formula

C₁₉H₁₃NO

CAS No.

3026677-37-9

Appearance

Solid

Color

Off-white to yellow

SMILES

OC(C1=C2C=CC=C1)=CC=C2C3=NC4=CC=CC=C4C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (460.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6858 mL	18.4291 mL	36.8582 mL
5 mM	0.7372 mL	3.6858 mL	7.3716 mL
10 mM	0.3686 mL	1.8429 mL	3.6858 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.85%

Select Batch:

Data Sheet (272 KB) SDS (0 KB)

COA (249 KB) HNMR (244 KB) LCMS (92 KB)

Handling Instructions (2659 KB)

References

[1]. Bhuktar H, et al. Design, synthesis and evaluation of 2-aryl quinoline derivatives against 12R-lipoxygenase (12R-LOX): Discovery of first inhibitor of 12R-LOX. Bioorg Chem. 2023 Sep;138:106606.. . [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.6858 mL	18.4291 mL	36.8582 mL	92.1455 mL
	5 mM	0.7372 mL	3.6858 mL	7.3716 mL	18.4291 mL
	10 mM	0.3686 mL	1.8429 mL	3.6858 mL	9.2146 mL
	15 mM	0.2457 mL	1.2286 mL	2.4572 mL	6.1430 mL
	20 mM	0.1843 mL	0.9215 mL	1.8429 mL	4.6073 mL
	25 mM	0.1474 mL	0.7372 mL	1.4743 mL	3.6858 mL
	30 mM	0.1229 mL	0.6143 mL	1.2286 mL	3.0715 mL
	40 mM	0.0921 mL	0.4607 mL	0.9215 mL	2.3036 mL
	50 mM	0.0737 mL	0.3686 mL	0.7372 mL	1.8429 mL
	60 mM	0.0614 mL	0.3072 mL	0.6143 mL	1.5358 mL
	80 mM	0.0461 mL	0.2304 mL	0.4607 mL	1.1518 mL
	100 mM	0.0369 mL	0.1843 mL	0.3686 mL	0.9215 mL

12R-LOX-IN-2 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

12R-LOX-IN-23026677-37-9LipoxygenaseDNA/RNA SynthesisLOX12R-lipoxygenasePsoriasisQuinolineSynthesisInhibitorinhibitorinhibit

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