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  3. Fluorescent Dye
  4. 6-NBDG

6-NBDG is a fluorescent glucose analogue, it can be used for fluorescence imaging and monitoring glucose transport and uptake. 6-NBDG can be used as a fluorescent probe for detecting macrophage-rich atherosclerotic plaques.

For research use only. We do not sell to patients.

6-NBDG Chemical Structure

6-NBDG Chemical Structure

CAS No. : 108708-22-1

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Based on 1 publication(s) in Google Scholar

6-NBDG Related Antibodies

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Description

6-NBDG is a fluorescent glucose analogue, it can be used for fluorescence imaging and monitoring glucose transport and uptake. 6-NBDG can be used as a fluorescent probe for detecting macrophage-rich atherosclerotic plaques[1][2].

In Vitro

Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Incubate sample with RPMI (without glucose) containing a final concentration of 200 μM 6-NBDG.
2. Use a curved forcep to embeds sample into the mixture, and stretches the samplet through a drop of agarose (40°C, 20 μL) places on a pre-heated (40°C) glass slide.
3. Gently place another preheated glass slide on the top of sample, so that the whole sample embeds into the agarose-6-NBDG mixture.
4. Take confocal images with a confocal laser scanning microscope (Ex: 471 nm, Em: 500–600 nm)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6-NBDG Related Antibodies
Molecular Weight

342.26

Formula

C12H14N4O8
CAS No.
Appearance

Solid

Color

Orange to red

Emission (Em)

542
Excitation (Ex)

488
SMILES

O=C[C@@H]([C@H]([C@@H]([C@@H](CNC1=CC=C([N+]([O-])=O)C2=NON=C21)O)O)O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (29.22 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9218 mL 14.6088 mL 29.2176 mL
5 mM 0.5844 mL 2.9218 mL 5.8435 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9218 mL 14.6088 mL 29.2176 mL 73.0439 mL
5 mM 0.5844 mL 2.9218 mL 5.8435 mL 14.6088 mL
10 mM 0.2922 mL 1.4609 mL 2.9218 mL 7.3044 mL
15 mM 0.1948 mL 0.9739 mL 1.9478 mL 4.8696 mL
20 mM 0.1461 mL 0.7304 mL 1.4609 mL 3.6522 mL
25 mM 0.1169 mL 0.5844 mL 1.1687 mL 2.9218 mL
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6-NBDG Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-NBDG108708-22-1Fluorescent Dyefluorescentglucoseanaloguefluorescence imagingtransportuptakeprobeInhibitorinhibitorinhibit

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