1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. GABA Receptor
  3. Afloqualone

Afloqualone  (Synonyms: HQ-495)

Cat. No.: HY-B1833 Purity: ≥98.0%
COA Handling Instructions

Afloqualone (HQ-495) is a GABAergic agent and has agonist activity at the β subtype of the GABAα receptor. Afloqualone has antivertiginous effects thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site.

For research use only. We do not sell to patients.

Afloqualone Chemical Structure

Afloqualone Chemical Structure

CAS No. : 56287-74-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 79 In-stock
Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Solid
100 mg USD 72 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

Afloqualone (HQ-495) is a GABAergic agent and has agonist activity at the β subtype of the GABAα receptor. Afloqualone has antivertiginous effects thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site[1].

Molecular Weight

283.30

Formula

C16H14FN3O

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=CC=CC=C2C)C(CF)=NC3=C1C=C(N)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 33 mg/mL (116.48 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5298 mL 17.6491 mL 35.2983 mL
5 mM 0.7060 mL 3.5298 mL 7.0597 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5298 mL 17.6491 mL 35.2983 mL 88.2457 mL
5 mM 0.7060 mL 3.5298 mL 7.0597 mL 17.6491 mL
10 mM 0.3530 mL 1.7649 mL 3.5298 mL 8.8246 mL
15 mM 0.2353 mL 1.1766 mL 2.3532 mL 5.8830 mL
20 mM 0.1765 mL 0.8825 mL 1.7649 mL 4.4123 mL
25 mM 0.1412 mL 0.7060 mL 1.4119 mL 3.5298 mL
30 mM 0.1177 mL 0.5883 mL 1.1766 mL 2.9415 mL
40 mM 0.0882 mL 0.4412 mL 0.8825 mL 2.2061 mL
50 mM 0.0706 mL 0.3530 mL 0.7060 mL 1.7649 mL
60 mM 0.0588 mL 0.2942 mL 0.5883 mL 1.4708 mL
80 mM 0.0441 mL 0.2206 mL 0.4412 mL 1.1031 mL
100 mM 0.0353 mL 0.1765 mL 0.3530 mL 0.8825 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Afloqualone
Cat. No.:
HY-B1833
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