1. Immunology/Inflammation Stem Cell/Wnt JAK/STAT Signaling
  2. Interleukin Related STAT
  3. Balsalazide sodium hydrate

Balsalazide sodium hydrate  (Synonyms: Balsalazide disodium dihydrate)

Cat. No.: HY-B0667A Purity: 99.61%
COA Handling Instructions

Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

For research use only. We do not sell to patients.

Balsalazide sodium hydrate Chemical Structure

Balsalazide sodium hydrate Chemical Structure

CAS No. : 150399-21-6

Size Price Stock Quantity
5 mg USD 50 In-stock
10 mg USD 75 In-stock
25 mg USD 130 In-stock
50 mg USD 195 In-stock
100 mg USD 290 In-stock
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Description

Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

IC50 & Target[1][2]

IL-6

 

IL-1

 

STAT3

 

In Vivo

At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

437.31

Formula

C17H17N3Na2O8

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)C1=CC(/N=N/C2=CC=C(C(NCCC(O[Na])=O)=O)C=C2)=CC=C1O[Na].O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (285.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (228.67 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2867 mL 11.4335 mL 22.8671 mL
5 mM 0.4573 mL 2.2867 mL 4.5734 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.2867 mL 11.4335 mL 22.8671 mL 57.1677 mL
5 mM 0.4573 mL 2.2867 mL 4.5734 mL 11.4335 mL
10 mM 0.2287 mL 1.1434 mL 2.2867 mL 5.7168 mL
15 mM 0.1524 mL 0.7622 mL 1.5245 mL 3.8112 mL
20 mM 0.1143 mL 0.5717 mL 1.1434 mL 2.8584 mL
25 mM 0.0915 mL 0.4573 mL 0.9147 mL 2.2867 mL
30 mM 0.0762 mL 0.3811 mL 0.7622 mL 1.9056 mL
40 mM 0.0572 mL 0.2858 mL 0.5717 mL 1.4292 mL
50 mM 0.0457 mL 0.2287 mL 0.4573 mL 1.1434 mL
60 mM 0.0381 mL 0.1906 mL 0.3811 mL 0.9528 mL
80 mM 0.0286 mL 0.1429 mL 0.2858 mL 0.7146 mL
100 mM 0.0229 mL 0.1143 mL 0.2287 mL 0.5717 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Balsalazide sodium hydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Balsalazide sodium hydrate
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