Benzyl alcohol (Synonyms: Benzenemethanol)

Cat. No.: HY-B0892 Purity: 99.95%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor. Benzyl alcohol is an inhibitor of P450 enzyme. Benzyl alcohol mediated Toll-Like Receptor 4 to reduce the inflammatory response of liver injury in mice.

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Benzyl alcohol Chemical Structure

CAS No. : 100-51-6

Size	Price	Stock	Quantity
Liquid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 33	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 33	In-stock	Estimated Time of Arrival: December 31
Liquid
5 g	USD 30	In-stock	Estimated Time of Arrival: December 31
10 g	USD 50	In-stock	Estimated Time of Arrival: December 31
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Other Forms of Benzyl alcohol:

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Biological Activity
Purity & Documentation
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Description

In Vitro

Benzyl alcohol (10-80 mM) regulates cyclic AMP synthesis in MDCK cells by increasing the membrane fluidity of intact renal epithelial cells^[1].
Benzyl alcohol (0-46 mM, 48 h) inhibits the hepatotoxicity of APAP by inhibiting cytochrome P450 enzyme activity in the primary liver of mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Benzyl alcohol (270 mg/kg, intraperitoneal injection, 0.5-24 h) can reduce the liver injury induced by acetaminophen^[2].
Benzyl alcohol (270 mg/kg, intraperitoneal injection, 3-24 h) decreases inflammasome activation in a TLR4-dependent manner^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	APAP-induced liver injury model in mice^[2]
Dosage:	270 mg/kg
Administration:	i.p.
Result:	Attenuated the increase in ALT activities and reduced areas of necrosis at both 6 h and 24 h. Reduced APAP metabolic activation and parameters of oxidant stress. Reduced APAP-induced mitochondrial dysfunction.

Clinical Trial

Molecular Weight

108.14

Formula

C₇H₈O

CAS No.

100-51-6

Appearance

Liquid

Color

Colorless to light yellow

SMILES

OCC1=CC=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : ≥ 100 mg/mL (924.73 mM)

H₂O : 20 mg/mL (184.95 mM; Need ultrasonic)

DMSO : ≥ 1.8 mg/mL (16.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	9.2473 mL	46.2364 mL	92.4727 mL
5 mM	1.8495 mL	9.2473 mL	18.4945 mL
10 mM	0.9247 mL	4.6236 mL	9.2473 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (23.12 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (23.12 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (23.12 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 33.33 mg/mL (308.21 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.95%

Select Batch:

Data Sheet (273 KB) SDS (453 KB)

COA (246 KB) RP-HPLC (216 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O / Ethanol	1 mM	9.2473 mL	46.2364 mL	92.4727 mL	231.1818 mL
	5 mM	1.8495 mL	9.2473 mL	18.4945 mL	46.2364 mL
	10 mM	0.9247 mL	4.6236 mL	9.2473 mL	23.1182 mL
	15 mM	0.6165 mL	3.0824 mL	6.1648 mL	15.4121 mL
H₂O / Ethanol	20 mM	0.4624 mL	2.3118 mL	4.6236 mL	11.5591 mL
	25 mM	0.3699 mL	1.8495 mL	3.6989 mL	9.2473 mL
	30 mM	0.3082 mL	1.5412 mL	3.0824 mL	7.7061 mL
	40 mM	0.2312 mL	1.1559 mL	2.3118 mL	5.7795 mL
	50 mM	0.1849 mL	0.9247 mL	1.8495 mL	4.6236 mL
	60 mM	0.1541 mL	0.7706 mL	1.5412 mL	3.8530 mL
	80 mM	0.1156 mL	0.5780 mL	1.1559 mL	2.8898 mL
	100 mM	0.0925 mL	0.4624 mL	0.9247 mL	2.3118 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benzyl alcohol100-51-6BenzenemethanolInhibitorinhibitorinhibit

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