1. Anti-infection Stem Cell/Wnt PI3K/Akt/mTOR Cell Cycle/DNA Damage Epigenetics
  2. Bacterial Antibiotic GSK-3 Aurora Kinase
  3. Ceftriaxone sodium hydrate

Ceftriaxone sodium hydrate  (Synonyms: Ro 13-9904 sodium hydrate)

Cat. No.: HY-B0712A Purity: 98.03%
COA Handling Instructions

Ceftriaxone sodium hydrate (Ro 13-9904 sodium hydrate) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone sodium hydrate is a covalent inhibitor of GSK3β with IC50 value of 0.78 μM. Ceftriaxone sodium hydrate is an inhibitor of Aurora B. Ceftriaxone sodium hydrate has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone sodium hydrate can be used in the study of bacterial infections and meningitis.

For research use only. We do not sell to patients.

Ceftriaxone sodium hydrate Chemical Structure

Ceftriaxone sodium hydrate Chemical Structure

CAS No. : 104376-79-6

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Based on 4 publication(s) in Google Scholar

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Description

Ceftriaxone sodium hydrate (Ro 13-9904 sodium hydrate) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone sodium hydrate is a covalent inhibitor of GSK3β with IC50 value of 0.78 μM. Ceftriaxone sodium hydrate is an inhibitor of Aurora B. Ceftriaxone sodium hydrate has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone sodium hydrate can be used in the study of bacterial infections and meningitis[1][2][3][4][5][6][7].

IC50 & Target

β-lactam

 

In Vitro

Ceftriaxone sodium hydrate (100 μM, 24 h) protects MPP+ treated astrocytes by inhibiting the NF-κB/JNK/c-Jun signaling pathway [3].
Ceftriaxone sodium hydrate (500 μM, 24-48 h) effectively inhibits unanchored cell growth in A549, H520 and H1650 lung cancer cells by inhibiting Aurora B[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: Astrocyte
Concentration: 100 μM
Incubation Time: 24 h
Result: Improved cell viability and increased glutamate uptake after MPP+ expose.

Western Blot Analysis[3]

Cell Line: Astrocyte
Concentration: 100 μM
Incubation Time: 24 h
Result: Enhanced GLT-1 and GFAP expression.
Decreased the expression of p-p50、p-IKKα、p-Relb.
Decreased the number of TUNEL-positive cells.
In Vivo

Ceftriaxone sodium hydrate (200 mg/kg Intraperitoneal injection for 6 weeks) improves functional markers and oxidative stress and inflammation parameters in a rat model of D-galactose (DGL) -induced liver and kidney injury[5].
Ceftriaxone sodium hydrate (200, 400 mg/kg, Intraperitoneal injection) has a protective effect on convulsion induced by Pentylenetetrazol (PTZ) and PTZ-related oxidative damage in rats[6].
Ceftriaxone sodium hydrate (100, 200 mg/kg, Intraperitoneal injection) reduces mechanical dysodynia and hyperalgesia by activating GLT-1 in Streptozocin (HY-13753)-induced diabetic rat models[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DGL-induced rat model[5]
Dosage: 200 mg/kg
Administration: i.p.
Result: Reduced the BUN、Cr 、AST and ALT levels.
Attenuated the MDA levels and enhanced GPx and CAT activities.
Reduced the levels of IL-1β and TNF-α mRNA.
Animal Model: PTZ-induced rat model[6]
Dosage: 200, 400 mg/kg
Administration: i.p. 60 min before to PTZ (70 mg/kg)
Result: Both of the two ceftriaxone groups had lower spike percentages than the saline group.
Significantly lower MDA levels and higher SOD activity in 200 and 400 mg/kg.
Clinical Trial
Molecular Weight

661.60

Formula

C18H23N8Na2O10.5S3

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])C(N12)=C(CSC(N(C)N=C3O[Na])=NC3=O)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O.[3.5H2O]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Purity & Documentation
References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Ceftriaxone sodium hydrate
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