1. GPCR/G Protein Neuronal Signaling
  2. mAChR
  3. Cevimeline hydrochloride

Cevimeline hydrochloride  (Synonyms: AF102B hydrochloride)

Cat. No.: HY-70020B Purity: ≥98.0%
COA Handling Instructions

Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline hydrochloride can cross the blood-brain barrier (BBB).

For research use only. We do not sell to patients.

Cevimeline hydrochloride Chemical Structure

Cevimeline hydrochloride Chemical Structure

CAS No. : 107220-28-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 140 In-stock
Solution
10 mM * 1 mL in Water USD 140 In-stock
Solid
5 mg USD 125 In-stock
10 mg USD 200 In-stock
50 mg USD 594 In-stock
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Other Forms of Cevimeline hydrochloride:

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Description

Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia[1][2][3][4]. Cevimeline hydrochloride can cross the blood-brain barrier (BBB)[5].

IC50 & Target

Muscarinic M1 and M3 receptor[1]

In Vitro

In digested parotid cells, Cevimeline (0.1-100 μM) increases the intracellular Ca2+ concentration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (8-week-old) injected with angiotensin-II[1]
Dosage: 0.008 mg/kg, 0.016 mg/kg
Administration: Intraperitoneal injection
Result: Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response.
Clinical Trial
Molecular Weight

235.77

Formula

C10H18ClNOS

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H]1SC[C@@]2(CN3CCC2CC3)O1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (212.07 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2414 mL 21.2071 mL 42.4142 mL
5 mM 0.8483 mL 4.2414 mL 8.4828 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.2414 mL 21.2071 mL 42.4142 mL 106.0355 mL
5 mM 0.8483 mL 4.2414 mL 8.4828 mL 21.2071 mL
10 mM 0.4241 mL 2.1207 mL 4.2414 mL 10.6036 mL
15 mM 0.2828 mL 1.4138 mL 2.8276 mL 7.0690 mL
20 mM 0.2121 mL 1.0604 mL 2.1207 mL 5.3018 mL
25 mM 0.1697 mL 0.8483 mL 1.6966 mL 4.2414 mL
30 mM 0.1414 mL 0.7069 mL 1.4138 mL 3.5345 mL
40 mM 0.1060 mL 0.5302 mL 1.0604 mL 2.6509 mL
50 mM 0.0848 mL 0.4241 mL 0.8483 mL 2.1207 mL
60 mM 0.0707 mL 0.3535 mL 0.7069 mL 1.7673 mL
80 mM 0.0530 mL 0.2651 mL 0.5302 mL 1.3254 mL
100 mM 0.0424 mL 0.2121 mL 0.4241 mL 1.0604 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cevimeline hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Cevimeline hydrochloride
Cat. No.:
HY-70020B
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