1. Anti-infection Stem Cell/Wnt JAK/STAT Signaling
  2. Antibiotic STAT
  3. Corylin

Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways.

For research use only. We do not sell to patients.

Corylin Chemical Structure

Corylin Chemical Structure

CAS No. : 53947-92-5

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 106 In-stock
Solution
10 mM * 1 mL in DMSO USD 106 In-stock
Solid
5 mg USD 96 In-stock
10 mg USD 132 In-stock
25 mg USD 211 In-stock
50 mg USD 274 In-stock
100 mg USD 357 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways[1][2][3].

In Vitro

Corylin (3-300 µM, 0-72 h) inhibits the proliferation of HepG2 and Huh7 cells[2].
Corylin (3-30 µM, 0-48 h) inhibits the migration and invasiveness of HepG2 and Huh7 cells by suppressing EMT[2].
Corylin (5-200 µM, 24 h) reduces the viability of 3T3-L1 preadipocytes at the doses of 100-200 µM[3].
Corylin (10 µM, 24 h) induces browning via the SIRT1 and β3-AR pathways in 3T3-L1 adipocytes[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: HepG2 and Huh7 cells
Concentration: 3-30 µM
Incubation Time: 24-48 h
Result: Reduced the expression of EMT-promoting proteins such as N-cadherin, vimentin, slug, and twist.
In Vivo

Corylin (60 mg/kg, i.p., three times a week, 4 weeks) inhibits tumor growth in Huh7 cells xenograft mice[3].
Corylin (50-100 mg/kg, p.o., daily, 9 weeks) improves the high-fat diet (HFD)-induced obesity in HFD- and DIO-treated mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HFD- and DIO-treated mice[3]
Dosage: 50-100 mg/kg
Administration: Oral gavage (p.o.), daily, 9 weeks
Result: Reduced the weight of subcutaneous, visceral WAT, and body.
Decreased the size of WAT adipocyte.
Increased insulin sensitivity, mitochondrial biogenesis, and β-oxidation.
Reduced serum levels of insulin and leptin and improved HOMA-IR.
Molecular Weight

320.34

Formula

C20H16O4

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1C(C2=CC=C3C(C=CC(C)(C)O3)=C2)=COC4=CC(O)=CC=C14

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (312.17 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1217 mL 15.6084 mL 31.2168 mL
5 mM 0.6243 mL 3.1217 mL 6.2434 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.80 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.97%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1217 mL 15.6084 mL 31.2168 mL 78.0421 mL
5 mM 0.6243 mL 3.1217 mL 6.2434 mL 15.6084 mL
10 mM 0.3122 mL 1.5608 mL 3.1217 mL 7.8042 mL
15 mM 0.2081 mL 1.0406 mL 2.0811 mL 5.2028 mL
20 mM 0.1561 mL 0.7804 mL 1.5608 mL 3.9021 mL
25 mM 0.1249 mL 0.6243 mL 1.2487 mL 3.1217 mL
30 mM 0.1041 mL 0.5203 mL 1.0406 mL 2.6014 mL
40 mM 0.0780 mL 0.3902 mL 0.7804 mL 1.9511 mL
50 mM 0.0624 mL 0.3122 mL 0.6243 mL 1.5608 mL
60 mM 0.0520 mL 0.2601 mL 0.5203 mL 1.3007 mL
80 mM 0.0390 mL 0.1951 mL 0.3902 mL 0.9755 mL
100 mM 0.0312 mL 0.1561 mL 0.3122 mL 0.7804 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Corylin
Cat. No.:
HY-N0236
Quantity:
MCE Japan Authorized Agent: