2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Ebastine

Ebastine  (Synonyms: LAS-W 090; RP64305)

Cat. No.: HY-B0674 Purity: 99.67%
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Ebastine (LAS-W 090) is an orally active, second-generation histamine H1 receptor antagonist. Ebastine can be used for the symptoms of allergic rhinitis and chronic idiopathic urticaria research.

For research use only. We do not sell to patients.

Ebastine Chemical Structure

Ebastine Chemical Structure

CAS No. : 90729-43-4

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 66 In-stock
Solid
500 mg USD 60 In-stock
1 g USD 84 In-stock
5 g USD 250 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Ebastine:

Ebastine Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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Description

Ebastine (LAS-W 090) is an orally active, second-generation histamine H1 receptor antagonist. Ebastine can be used for the symptoms of allergic rhinitis and chronic idiopathic urticaria research[1].

IC50 & Target[1]

H1 Receptor

 

In Vitro

Ebastine (10-500 ng/mL; 24-48 hours) treatment significantly increases the proliferation of HFDPC[2].
Ebastine (10-500 ng/mL; 24-48 hours) treatment shows dose-dependent increases in Cyclin D1, Cyclin E1, and Cyclin A expression levels. And the expression levels of Cdk4, Cdk2, and Cdc2 are alos increased. Ebastine treatment elevates expression levels of phospho-AKT and phospho-p44/42 extracellular signal-regulated kinase[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ebastine Related Antibodies

Cell Proliferation Assay[2]

Cell Line: Human follicle dermal papilla cells (HFDPC)
Concentration: 10 ng/mL, 50 ng/mL, 100 ng/mL, 200 ng/mL, 500 ng/mL
Incubation Time: 24 hours, 48 hours
Result: The proliferative activity in cells was significantly enhanced.

Western Blot Analysis[2]

Cell Line: Human follicle dermal papilla cells (HFDPC)
Concentration: 10 ng/mL, 50 ng/mL, 100 ng/mL, 200 ng/mL, 500 ng/mL
Incubation Time: 24 hours
Result: The expression levels of cell-cycle regulatory proteins and an antiapoptotic protein were increased in HFDPC.
In Vivo

In rats, after intravenous administration of [14C]Ebastine at 2 mg/kg, the plasma level of radioactivity decreased biphasically with α-phase half-life (t1/2 α) of 1.6 h and β-phase half-life (t1/2 β) of 3.1 h[3].
Following oral administration of [14C]Ebastine at a dose of 2 mg/kg, the plasma level reached the maximum (Cmax) of 102 ng eq./ml at 2 h and decreased monophasically with t1/2 of 3.9 h. At 20 mg/kg, a monophasic decrease is also observed with Cmax of 1110 ng eq./ml at 4 h and with t1/2 of 4.0 h[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

469.66

Formula

C32H39NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C(C)(C)C)C=C1)CCCN2CCC(OC(C3=CC=CC=C3)C4=CC=CC=C4)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

Ethanol : 58.75 mg/mL (125.09 mM; Need ultrasonic)

DMSO : 8.33 mg/mL (17.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1292 mL 10.6460 mL 21.2920 mL
5 mM 0.4258 mL 2.1292 mL 4.2584 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol 1 mM 2.1292 mL 10.6460 mL 21.2920 mL 53.2300 mL
5 mM 0.4258 mL 2.1292 mL 4.2584 mL 10.6460 mL
10 mM 0.2129 mL 1.0646 mL 2.1292 mL 5.3230 mL
15 mM 0.1419 mL 0.7097 mL 1.4195 mL 3.5487 mL
Ethanol 20 mM 0.1065 mL 0.5323 mL 1.0646 mL 2.6615 mL
25 mM 0.0852 mL 0.4258 mL 0.8517 mL 2.1292 mL
30 mM 0.0710 mL 0.3549 mL 0.7097 mL 1.7743 mL
40 mM 0.0532 mL 0.2661 mL 0.5323 mL 1.3307 mL
50 mM 0.0426 mL 0.2129 mL 0.4258 mL 1.0646 mL
60 mM 0.0355 mL 0.1774 mL 0.3549 mL 0.8872 mL
80 mM 0.0266 mL 0.1331 mL 0.2661 mL 0.6654 mL
100 mM 0.0213 mL 0.1065 mL 0.2129 mL 0.5323 mL
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Ebastine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ebastine90729-43-4LAS-W 090 RP64305RP64305RP 64305RP-64305Histamine ReceptorantihistamineantiallergicallergicrhinitisidiopathicurticariaInhibitorinhibitorinhibit

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