Fenoterol hydrobromide (Synonyms: Th-1165a; Phenoterol hydrobromide)

Cat. No.: HY-B0976A Purity: 99.90%: FAQs
Data Sheet SDS COA Handling Instructions

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Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research.

For research use only. We do not sell to patients.

Fenoterol hydrobromide Chemical Structure

CAS No. : 1944-12-3

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 93	In-stock	Estimated Time of Arrival: December 31
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10 mM * 1 mL in DMSO	USD 93	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 84	In-stock	Estimated Time of Arrival: December 31
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Other Forms of Fenoterol hydrobromide:

Fenoterol In-stock
Fenoterol-d₆ hydrobromide In-stock
Fenoterol hydrobromide (Standard) Get quote

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Biological Activity
Purity & Documentation
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Description

In Vitro

Fenoterol (1 μM; pre-incubated 30 minutes) treatment reduces AICAR-induced AMPK activation, NF-κB activation and TNF-α release, and also significantly downregulates the elevated phosphorylation levels of AMPK^[2].
Fenoterol inhibits lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells^[2].
Fenoterol is also a potent exosome biogenesis and/or secretion activator in PC cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	THP-1 cells stimulated with AICAR
Concentration:	1 μM
Incubation Time:	Pre-incubated 30 minutes
Result:	Significantly downregulated the elevated phosphorylation levels of AMPK.

In Vivo

Fenoterol (0.7 mg/kg; intraperitoneal injection; twice a day; for 3 weeks) treatment suppresses mechanical allodynia during chronic treatment^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6J mice (6 weeks old) with neuropathy^[3]
Dosage:	0.7 mg/kg
Administration:	Intraperitoneal injection; twice a day; for 3 weeks
Result:	Alleviated neuropathic allodynia during chronic treatment.

Clinical Trial

Molecular Weight

384.26

Formula

C₁₇H₂₂BrNO₄

CAS No.

1944-12-3

Appearance

Solid

Color

White to off-white

SMILES

[H]Br.OC1=CC(C(O)CNC(C)CC2=CC=C(O)C=C2)=CC(O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (260.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 25 mg/mL (65.06 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6024 mL	13.0120 mL	26.0240 mL
5 mM	0.5205 mL	2.6024 mL	5.2048 mL
10 mM	0.2602 mL	1.3012 mL	2.6024 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.51 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.51 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.51 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 60 mg/mL (156.14 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (245 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.6024 mL	13.0120 mL	26.0240 mL	65.0601 mL
	5 mM	0.5205 mL	2.6024 mL	5.2048 mL	13.0120 mL
	10 mM	0.2602 mL	1.3012 mL	2.6024 mL	6.5060 mL
	15 mM	0.1735 mL	0.8675 mL	1.7349 mL	4.3373 mL
	20 mM	0.1301 mL	0.6506 mL	1.3012 mL	3.2530 mL
	25 mM	0.1041 mL	0.5205 mL	1.0410 mL	2.6024 mL
	30 mM	0.0867 mL	0.4337 mL	0.8675 mL	2.1687 mL
	40 mM	0.0651 mL	0.3253 mL	0.6506 mL	1.6265 mL
	50 mM	0.0520 mL	0.2602 mL	0.5205 mL	1.3012 mL
	60 mM	0.0434 mL	0.2169 mL	0.4337 mL	1.0843 mL
DMSO	80 mM	0.0325 mL	0.1627 mL	0.3253 mL	0.8133 mL
DMSO	100 mM	0.0260 mL	0.1301 mL	0.2602 mL	0.6506 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fenoterol1944-12-3Th-1165aPhenoterolInhibitorinhibitorinhibit

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