2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. GLPG0634 analog

GLPG0634 analog (Compoun 176) is a broad spectrum JAK inhibitor with IC50 values of <100 nM against JAK1, JAK2 and JAK3.

For research use only. We do not sell to patients.

GLPG0634 analog Chemical Structure

GLPG0634 analog Chemical Structure

CAS No. : 1206101-20-3

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10 mM * 1 mL in DMSO
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Other Forms of GLPG0634 analog:

GLPG0634 analog Related Antibodies

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JAK1 JAK2 JAK3 Tyk2 JAK

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Description

GLPG0634 analog (Compoun 176) is a broad spectrum JAK inhibitor with IC50 values of <100 nM against JAK1, JAK2 and JAK3[1].

IC50 & Target[3]

JAK1

<100 nM (IC50)

JAK2

<100 nM (IC50)

JAK3

<100 nM (IC50)

Tyk2

<100 nM (IC50)

In Vitro

GLPG0634 analog (Compoun 176) inhibits JAK-STAT signaling and OSM/IL-lβ signaling with both EC50 values of 101-500 nM[1].
GLPG0634 analog shows microsomal stability of 76%-100% in rat and human[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GLPG0634 analog Related Antibodies
Molecular Weight

410.43

Formula

C23H18N6O2
CAS No.
Appearance

Solid

Color

Light yellow to khaki

SMILES

O=C(C1CC1)NC2=NN3C(C4=CC=C(OCC5=CC=C(C#N)N=C5)C=C4)=CC=CC3=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 53 mg/mL (129.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4365 mL 12.1823 mL 24.3647 mL
5 mM 0.4873 mL 2.4365 mL 4.8729 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4365 mL 12.1823 mL 24.3647 mL 60.9117 mL
5 mM 0.4873 mL 2.4365 mL 4.8729 mL 12.1823 mL
10 mM 0.2436 mL 1.2182 mL 2.4365 mL 6.0912 mL
15 mM 0.1624 mL 0.8122 mL 1.6243 mL 4.0608 mL
20 mM 0.1218 mL 0.6091 mL 1.2182 mL 3.0456 mL
25 mM 0.0975 mL 0.4873 mL 0.9746 mL 2.4365 mL
30 mM 0.0812 mL 0.4061 mL 0.8122 mL 2.0304 mL
40 mM 0.0609 mL 0.3046 mL 0.6091 mL 1.5228 mL
50 mM 0.0487 mL 0.2436 mL 0.4873 mL 1.2182 mL
60 mM 0.0406 mL 0.2030 mL 0.4061 mL 1.0152 mL
80 mM 0.0305 mL 0.1523 mL 0.3046 mL 0.7614 mL
100 mM 0.0244 mL 0.1218 mL 0.2436 mL 0.6091 mL
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GLPG0634 analog Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GLPG06341206101-20-3GLPG 0634GLPG-0634JAKJanus kinaseHela cellAK-STATOSM/IL-lβInhibitorinhibitorinhibit

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