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  4. GSK-J2

GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.

For research use only. We do not sell to patients.

GSK-J2 Chemical Structure

GSK-J2 Chemical Structure

CAS No. : 1394854-52-4

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 136 In-stock
Solution
10 mM * 1 mL in DMSO USD 136 In-stock
Solid
5 mg USD 80 In-stock
10 mg USD 124 In-stock
50 mg USD 450 In-stock
100 mg USD 750 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of GSK-J2:

GSK-J2 Related Antibodies

Top Publications Citing Use of Products

    GSK-J2 purchased from MedChemExpress. Usage Cited in: Front Mol Neurosci. 2017 Mar 13;10:51.  [Abstract]

    GSK-J1 impaired zebrafish hair cell regeneration. 5 dpf larvae are treated with 400 μM Neomycin for 1 h followed by GSK-J1 exposure for 24 in the presence of BrdU. GSK-J1 significantly reduces the numbers of myosinVI-positive (green) hair cells and BrdU-positive (red) replicating cells.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.

    In Vitro

    GSK-J2 is an isomer of GSK-J1, and shows poor activity towards KDM6A and KDM6B, with IC50 of > 100 μM and 49 μM, respectively[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    GSK-J2 Related Antibodies
    Molecular Weight

    389.45

    Formula

    C22H23N5O2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O)CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 42 mg/mL (107.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5677 mL 12.8386 mL 25.6772 mL
    5 mM 0.5135 mL 2.5677 mL 5.1354 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    C2

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    Volume (final)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.5677 mL 12.8386 mL 25.6772 mL 64.1931 mL
    5 mM 0.5135 mL 2.5677 mL 5.1354 mL 12.8386 mL
    10 mM 0.2568 mL 1.2839 mL 2.5677 mL 6.4193 mL
    15 mM 0.1712 mL 0.8559 mL 1.7118 mL 4.2795 mL
    20 mM 0.1284 mL 0.6419 mL 1.2839 mL 3.2097 mL
    25 mM 0.1027 mL 0.5135 mL 1.0271 mL 2.5677 mL
    30 mM 0.0856 mL 0.4280 mL 0.8559 mL 2.1398 mL
    40 mM 0.0642 mL 0.3210 mL 0.6419 mL 1.6048 mL
    50 mM 0.0514 mL 0.2568 mL 0.5135 mL 1.2839 mL
    60 mM 0.0428 mL 0.2140 mL 0.4280 mL 1.0699 mL
    80 mM 0.0321 mL 0.1605 mL 0.3210 mL 0.8024 mL
    100 mM 0.0257 mL 0.1284 mL 0.2568 mL 0.6419 mL
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    GSK-J2 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    GSK-J21394854-52-4OthersInhibitorinhibitorinhibit

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    Product Name:
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    Cat. No.:
    HY-15648A
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