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Gadobutrol  (Synonyms: ZK 135079)

Cat. No.: HY-16217 Purity: 99.58%
COA Handling Instructions

Gadobutrol (Gd-DO3A-butrol; ZK 135079) is a nonionic paramagnetic macrocyclic gadolinium-based contrast agent that can be used for magnetic resonance imaging (MRI).

For research use only. We do not sell to patients.

Gadobutrol Chemical Structure

Gadobutrol Chemical Structure

CAS No. : 770691-21-9

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 96 In-stock
Solution
10 mM * 1 mL in Water USD 96 In-stock
Solid
5 mg USD 72 In-stock
10 mg USD 86 In-stock
50 mg USD 130 In-stock
100 mg USD 156 In-stock
200 mg USD 190 In-stock
500 mg   Get quote  
1 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Gadobutrol:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Gadobutrol

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Gadobutrol (Gd-DO3A-butrol; ZK 135079) is a nonionic paramagnetic macrocyclic gadolinium-based contrast agent that can be used for magnetic resonance imaging (MRI)[1].

In Vitro

Gadobutrol leads to a gradual decrease in cell density with increasing concentration under neutron irradiation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human melanoma cell line Sk-Mel-28
Concentration: 0-30 mM
Incubation Time: 1 hour
Result: Showed a decrease in cell density to 26% at 30 mM while to 80% with no gadobutrol under neutron irradiation.
In Vivo

Gadobutrol (intravenous injection, 200 mM, once, a week) can significantly enhance intracerebroventricular cell signaling in female C57BL/6 N mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 N mice, 11-13 weeks, 21-23 g)[2]
Dosage: 200 mM
Administration: Intravenous injection; once; a week
Result: Enhanced cells signal in the habenula, hippocampal formation, and locus coeruleus.
Clinical Trial
Molecular Weight

604.71

Formula

C18H31GdN4O9

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@H]1[N]23[Gd+3]([N]4(C5)CC3)([N]6(C7)CC4)([OH][C@@H]1CO)([O-]C5=O)([O-]C8=O)([O-]C7=O)[N](CC6)(C8)CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 20 mg/mL (33.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6537 mL 8.2684 mL 16.5369 mL
5 mM 0.3307 mL 1.6537 mL 3.3074 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (82.68 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.6537 mL 8.2684 mL 16.5369 mL 41.3421 mL
5 mM 0.3307 mL 1.6537 mL 3.3074 mL 8.2684 mL
10 mM 0.1654 mL 0.8268 mL 1.6537 mL 4.1342 mL
15 mM 0.1102 mL 0.5512 mL 1.1025 mL 2.7561 mL
20 mM 0.0827 mL 0.4134 mL 0.8268 mL 2.0671 mL
25 mM 0.0661 mL 0.3307 mL 0.6615 mL 1.6537 mL
30 mM 0.0551 mL 0.2756 mL 0.5512 mL 1.3781 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Gadobutrol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Gadobutrol
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