2. Anti-infection Apoptosis Metabolic Enzyme/Protease
  3. Parasite Bacterial Apoptosis Glucosidase Endogenous Metabolite
  4. Hexylresorcinol

Hexylresorcinol  (Synonyms: 4-Hexylresorcinol)

Cat. No.: HY-B0986 Purity: 99.52%
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Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage.

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Hexylresorcinol Chemical Structure

Hexylresorcinol Chemical Structure

CAS No. : 136-77-6

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Based on 1 publication(s) in Google Scholar

Hexylresorcinol Related Antibodies

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Description

Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage[1][2][3][4][5].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Hexylresorcinol potently inhibits Gram positive bacteria, with MICs of 20-50 mg/L for several Gram positive bacteria. Gram negative bacteria, yeasts and fungi are less sensitive to it[1].
Hexylresorcinol inhibits oxidative DNA damage in human lymphocytes by increasing levels of glutathione and modulation of antioxidant enzymes (GPX, GR and GST)[2].
Hexylresorcinol (1-10 µg/mL; 24-72 hours) suppresses squamous carcinoma cell line SCC-9 proliferation[3].
Hexylresorcinol has strong antitumor effects by inhibiting calcium channel oscillation and inducing apoptosis[3].
Hexylresorcinol upregulates TGF-β/SMAD/VEGF signaling in endothelial cells and induces vascular regeneration and remodeling for wound healing[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hexylresorcinol Related Antibodies

Cell Proliferation Assay[3]

Cell Line: SCC-9 cells
Concentration: 1 µg/mL, 5 µg/mL, 10 µg/mL
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Inhibited SCC-9 cells proliferation.

Apoptosis Analysis[3]

Cell Line: SCC-9 cells
Concentration: 10 µg/mL
Incubation Time: 24 hours
Result: Induced morphological and biochemical changes in SCC-9 cells.
In Vivo

Hexylresorcinol (10 mg/kg; i.p.; daily; for 16 days) inhibits tumor cell proliferation in mouse tumor xenografts and concomitant application of calcium channel blocker partly reverses the antitumor effect of Hexylresorcinol[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male nude mice (BALB/cAnNCrj-nu/nu), with SCC-9 cells xenograft[3]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection, daily, for 16 days
Result: Reduced tumor formation in vivo.
Molecular Weight

194.27

Formula

C12H18O2
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

OC1=CC=C(CCCCCC)C(O)=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1286.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 100 mg/mL (514.75 mM; Need ultrasonic)

H2O : 1 mg/mL (5.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.1475 mL 25.7374 mL 51.4748 mL
5 mM 1.0295 mL 5.1475 mL 10.2950 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.52%

COA (242 KB) LCMS (86 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / Ethanol / DMSO 1 mM 5.1475 mL 25.7374 mL 51.4748 mL 128.6869 mL
5 mM 1.0295 mL 5.1475 mL 10.2950 mL 25.7374 mL
Ethanol / DMSO 10 mM 0.5147 mL 2.5737 mL 5.1475 mL 12.8687 mL
15 mM 0.3432 mL 1.7158 mL 3.4317 mL 8.5791 mL
20 mM 0.2574 mL 1.2869 mL 2.5737 mL 6.4343 mL
25 mM 0.2059 mL 1.0295 mL 2.0590 mL 5.1475 mL
30 mM 0.1716 mL 0.8579 mL 1.7158 mL 4.2896 mL
40 mM 0.1287 mL 0.6434 mL 1.2869 mL 3.2172 mL
50 mM 0.1029 mL 0.5147 mL 1.0295 mL 2.5737 mL
60 mM 0.0858 mL 0.4290 mL 0.8579 mL 2.1448 mL
80 mM 0.0643 mL 0.3217 mL 0.6434 mL 1.6086 mL
100 mM 0.0515 mL 0.2574 mL 0.5147 mL 1.2869 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Hexylresorcinol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hexylresorcinol136-77-64-HexylresorcinolParasiteBacterialApoptosisGlucosidaseEndogenous Metaboliteantisepticanthelminticlocalanestheticanti-proliferativecancerchemopreventivenasopharyngealsquamouscellcarcinomatype-2diabetesangiogenesisInhibitorinhibitorinhibit

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