2. Anti-infection
  3. Bacterial
  4. LED209

LED209 is a potent and orally active small molecule inhibitor of the bacterial receptor QseC and a potent prodrug with high selectivity for QseC. LED209 inhibits the binding of signaling molecules to QseC. LED209 has antibacterial activity.

For research use only. We do not sell to patients.

LED209 Chemical Structure

LED209 Chemical Structure

CAS No. : 245342-14-7

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5 mg USD 31 In-stock
10 mg USD 50 In-stock
50 mg USD 220 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

LED209 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

LED209 is a potent and orally active small molecule inhibitor of the bacterial receptor QseC and a potent prodrug with high selectivity for QseC. LED209 inhibits the binding of signaling molecules to QseC. LED209 has antibacterial activity[1].

In Vitro

LED209 (5 nM, 24 h) decreases biofilm formation in EAEC O104:H4 and several multidrug-resistant clinical isolates of rUTIs[1].
LED209 (7.5-30 μM, 0-80 h) reduces L. pneumophila replication with IC50 values of 1.27 µM and 50.6 µM respectively[2].
LED209 (5 pM) inhibits the binding of signals (norepinephrine) to QseC, preventing QseC autophosphorylation and inhibiting QseC-mediated activation of virulence gene expression[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LED209 Related Antibodies
In Vivo

LED209 (20 mg/kg, p.o., a single dose at 30 min prior to intraperitoneal injection of S. Typhimurium) protects mice against S. Typhimurium and F. tularensis murine infections, as well as F. tularensis murine infections (administered orally to mice either 1, 3, 6, 9, or 24 h prior to infection)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

383.49

Formula

C19H17N3O2S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(NC(NC2=CC=CC=C2)=S)C=C1)(NC3=CC=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (651.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6076 mL 13.0381 mL 26.0763 mL
5 mM 0.5215 mL 2.6076 mL 5.2153 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.87%

COA (247 KB) HNMR (276 KB) LCMS (269 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6076 mL 13.0381 mL 26.0763 mL 65.1907 mL
5 mM 0.5215 mL 2.6076 mL 5.2153 mL 13.0381 mL
10 mM 0.2608 mL 1.3038 mL 2.6076 mL 6.5191 mL
15 mM 0.1738 mL 0.8692 mL 1.7384 mL 4.3460 mL
20 mM 0.1304 mL 0.6519 mL 1.3038 mL 3.2595 mL
25 mM 0.1043 mL 0.5215 mL 1.0431 mL 2.6076 mL
30 mM 0.0869 mL 0.4346 mL 0.8692 mL 2.1730 mL
40 mM 0.0652 mL 0.3260 mL 0.6519 mL 1.6298 mL
50 mM 0.0522 mL 0.2608 mL 0.5215 mL 1.3038 mL
60 mM 0.0435 mL 0.2173 mL 0.4346 mL 1.0865 mL
80 mM 0.0326 mL 0.1630 mL 0.3260 mL 0.8149 mL
100 mM 0.0261 mL 0.1304 mL 0.2608 mL 0.6519 mL
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LED209 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LED209245342-14-7LED 209LED-209BacterialQseCantibacterialinfectionInhibitorinhibitorinhibit

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