Search Result
Results for "
Lipopolysaccharides
" in MedChemExpress (MCE) Product Catalog:
2
Biochemical Assay Reagents
6
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-D1056
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LPS
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Toll-like Receptor (TLR)
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Inflammation/Immunology
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Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells . This product is derived from Escherichia coli O55:B5. Lipopolysaccharides induces secretion of cell migrasome .
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-
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- HY-106947
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Endogenous Metabolite
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Metabolic Disease
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SY-640 is an Acetamide derivative and has potent hepatoprotective effect. SY-640 reduces Propionibacterium acnes and Lipopolysaccharide-induced liver injury in mice .
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-
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- HY-131306
-
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Others
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Others
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Δ2-cis-Hexadecenoic acid is an unsaturated fatty acid that is a hydrolysate of lipopolysaccharide (HY-D1056) .
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-
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- HY-157492
-
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Bacterial
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Infection
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RO7075573 (compound 3) is an antibiotics that targets the lipopolysaccharide (LPS) transport machine in Acinetobacter. RO7075573 protects mice from A. baumannii infections .
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-
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- HY-N9297
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(+)-Oxyphyllenone A
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NO Synthase
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Inflammation/Immunology
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Oxyphyllenone A is an inhibitor of NO Synthase. Oxyphyllenone A inhibits the NO production in lipopolysaccharide-activated macrophages with an IC50 of 28 μM .
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-
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- HY-N8277
-
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Toll-like Receptor (TLR)
TNF Receptor
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Others
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Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both TNF and PGE2 .
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-
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- HY-144280
-
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Bacterial
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Infection
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MsbA-IN-2 (compound 12) is a potent lipopolysaccharide transporter MsbA inhibitor with an IC50 of 2 nM for E. coli MsbA .
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-
-
- HY-119720
-
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NF-κB
NO Synthase
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Inflammation/Immunology
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Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways .
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-
-
- HY-14180
-
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IKK
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Inflammation/Immunology
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PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation .
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-
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- HY-12085
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-
-
- HY-138989
-
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Lipoxygenase
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Inflammation/Immunology
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15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation .
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-
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- HY-N8160
-
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Keap1-Nrf2
Reactive Oxygen Species
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Inflammation/Immunology
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Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity .
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-
-
- HY-110275
-
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Keap1-Nrf2
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Others
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RA839 is a noncovalent small molecule binder to Keap1 with a Kd of ∼6 μM and selective activator of Nrf2 signaling. RA839 prevents the induction of both inducible nitric-oxide synthase expression and nitric oxide release in response to lipopolysaccharides in macrophages. RA839 is a selective inhibitor of the Keap1/Nrf2 interaction and a useful tool compound to study the biology of Nrf2 .
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-
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- HY-130004
-
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Antibiotic
Bacterial
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Infection
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MsbA-IN-6 is a potent inhibitor of MsbA. MsbA-IN-6 is an antibiotic. Gram-negative ATP-binding cassette (ABC) transporter MsbA, an essential inner membrane protein, transports lipopolysaccharide from the inner leaflet to the periplasmic face of the inner membrane. MsbA-IN-6 kills Escherichia coli through inhibition of its ATPase and transport activity, with no loss of activity against clinical multidrug-resistant strains .
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- HY-P3496
-
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Pyroptosis
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Inflammation/Immunology
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Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis .
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-
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- HY-148552
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p38 MAPK
ERK
NF-κB
Interleukin Related
TNF Receptor
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Inflammation/Immunology
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Anti-inflammatory agent 35 (compound 5a27) is an orally active curcumin analogue with anti-inflammatory activity. Anti-inflammatory agent 35 blocks mitogen-activated protein kinase (MAPK) signaling and p65 nuclear translocation of NF-kB. Anti-inflammatory agent 35 also inhibits yellow neutrophil infiltration and pro-inflammatory cytokine production. Anti-inflammatory agent 35 significantly attenuates lipopolysaccharide (LPS)-induced acute lung injury (ALI) in vivo .
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-
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- HY-P1674A
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POL7080 TFA
|
Bacterial
Antibiotic
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Infection
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Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with MIC50 and MIC90 values both of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance .
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-
-
- HY-P1674
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POL7080
|
Bacterial
Antibiotic
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Infection
|
Murepavadin (POL7080), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with both MIC50 and MIC90 values of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance .
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-
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- HY-N3182
-
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Others
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Neurological Disease
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N-Methylnuciferine, an alkaloid from Lotus Plumule, ameliorate lipopolysaccharide-induced depression-like behavior .
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-
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- HY-N10066
-
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Others
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Inflammation/Immunology
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Anti-inflammatory agent 5 displays potent inhibition of NO generation in lipopolysaccharide-induced BV-2 microglial cells.
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- HY-147429A
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Abx MCP TFA; RG6006 TFA
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Antibiotic
Bacterial
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Infection
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Zosurabalpin TFA is a tethered macrocyclic peptide antibiotic, acting specifically on A. baumannii. Zosurabalpin TFA inhibits lipopolysaccharide-transport .
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-
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- HY-117601
-
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Others
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Inflammation/Immunology
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11-Deoxyalisol B, a triterpene, shows the potent inhibitory activity on Lipopolysaccharide (LPS)-induced nitric oxide (NO) production .
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-
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- HY-N6946
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Others
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Inflammation/Immunology
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Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils .
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-
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- HY-N11028
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Others
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Inflammation/Immunology
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Isophysalin G is a steroid that inhibits NO production induced by Lipopolysaccharides (HY-D1056) in macrophages with an IC50 of 64.01 μM .
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-
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- HY-A0089
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Polymyxin E sulfate
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Bacterial
Autophagy
Antibiotic
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Infection
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Colistin sulfate is a polypeptide antibiotic which inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria.
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-
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- HY-N5015
-
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COX
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Inflammation/Immunology
Cancer
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Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.
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-
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- HY-P10159
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Bacterial
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Infection
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Diplacol ia a natural compound from from Mimulus clevelandi and shows potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production .
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-
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- HY-N3473
-
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NO Synthase
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Neurological Disease
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Isomaculosidine is an alkaloid that can be isolated from D. dasycarpus. Isomaculosidine can inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 microglial cells .
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- HY-N9675
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NO Synthase
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Inflammation/Immunology
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(+)-Hannokinol can be isolated from AMOMUM TSAO-KO (ginger family) fruit. (+)-Hannokinol inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia .
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-
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- HY-B0289
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-
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- HY-104073
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-
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- HY-N2195
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(+)-Nootkatone
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|
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Nootkatone, a neuroprotective agent from Vitis vinifera, has antioxidant and anti-inflammatory effects . Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease .
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-
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- HY-N10275
-
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Others
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Inflammation/Immunology
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Herpotrichone A shows potent anti-neuroinflammatory activity in lipopolysaccharide (LPS)-induced BV-2 microglial cells with the half maximal inhibitory concentration (IC50) value of 0.41 μM.
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-
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- HY-N10445
-
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CD28
CD3
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Inflammation/Immunology
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Maydispenoid A is a potent immunosuppressor. Maydispenoid A can inhibit anti-CD3/anti-CD28 mAbs activated and lipopolysaccharide activated murine splenocyte proliferation .
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-
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- HY-N4243
-
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Others
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Metabolic Disease
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Neocurdione is a hepatoprotective sesquiterpene isolated from Curcuma zedoaria rhizome. Neocurdione exerts potent effect on D-galactosamine- (D-Gain) and lipopolysaccharide- (LPS) induced acute liver injury in mice .
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-
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- HY-N10274
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-
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- HY-N1494
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14-Deoxy-ε-caesalpin
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NO Synthase
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Inflammation/Immunology
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(+)-14-Deoxy-ε-caesalpin (14-Deoxy-ε-caesalpin), a cassane diterpenoid, inhibits nitric oxide (NO) production release of RAW 264.7 cells stimulated by Lipopolysaccharide (LPS) .
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- HY-N10446
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CD28
CD3
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Inflammation/Immunology
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Maydispenoid B is a potent immunosuppressor. Maydispenoid B can inhibit anti-CD3/anti-CD28 mAbs activated and lipopolysaccharide activated murine splenocyte proliferation .
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-
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- HY-107352
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-
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- HY-108644
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-
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- HY-N11544
-
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NO Synthase
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Inflammation/Immunology
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Inflexuside B, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages .
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- HY-N11548
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NO Synthase
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Inflammation/Immunology
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Inflexuside A, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO production (NO Synthase) in RAW264.7 macrophages .
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- HY-N1546
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Protoplumericin A is a bioactive ingredient of Plumeria obtusa L. attenuates. Protoplumericin A mitigated lipopolysaccharide (LPS) -induced acute lung injury in mice. Protoplumericin A can be used to study the LPS-induced anti-inflammatory effect .
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-
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- HY-103017
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IRAK
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Infection
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JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 hydrochloride ameliorates LPS-induced sepsis in mice .
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- HY-N1912
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Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .
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- HY-N8129
-
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Others
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Others
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Rhaponticin 6′′-O-gallate is a stilbene glucoside gallate that can be found in rhizome of Rheum undulatum L. Rhaponticin 6′′-O-gallate inhibits nitric oxide production in lipopolysaccharide-activated macrophages .
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- HY-110343
-
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TNF Receptor
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Inflammation/Immunology
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DBM 1285 dihydrochloride is an orally active TNF-α production inhibitor with anti-inflammatory effects. DBM 1285 dihydrochloride inhibits Lipopolysaccharide (LPS)-induced TNF-α secretion in various cells of macrophage/monocyte lineage .
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-
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- HY-N2391
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-
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- HY-N10277
-
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Others
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Neurological Disease
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Inubritannolide A displays slight strong neuroprotective potency against different types of neuronal cells mediated by various inducers including H2O2, 6-hydroxydopamine (6-OHDA), and lipopolysaccharide (LPS).
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- HY-N2556
-
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Others
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Inflammation/Immunology
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Tirucallol, a tetracyclic triterpene, is isolated from Euphorbia lacteal latex. Tirucallol has topical anti-inflammatory effect. Tirucallol can suppress ear edema in the mouse model and inhibit nitrite production in lipopolysaccharide-stimulated macrophages .
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- HY-N1195
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(+)-Sugiol; 10-Deoxoxanthoperol
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|
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Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages .
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- HY-131521
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Oxalomalate trisodium
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Isocitrate Dehydrogenase (IDH)
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Cancer
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Oxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages .
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- HY-106739
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NAT 05-239
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Phosphodiesterase (PDE)
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Inflammation/Immunology
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Motapizone (NAT 05-239) is a selective PDE3 inhibitor. Motapizone moderately inhibits cytokine release in lipopolysaccharide (LPS)-induced alveolar macrophages. Motapizone also inhibits human platelet aggregation by increasing intracellular cAMP .
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- HY-N12429
-
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Others
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Inflammation/Immunology
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Marstenacisside F1 (compound 1) is a polyoxypregnanoside with anti-inflammatory activity isolated from Marsdenia tenacissima. Marstenacisside F1 inhibits lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 cells and is a derivative of Tenacigenin B.
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- HY-N1695
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Regelin acid
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NO Synthase
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Inflammation/Immunology
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Demethylregelin (Regelin acid), a triterpene, effectively reduces the expression of iNOS protein and subsequent nitric oxide production induced by lipopolysaccharide (HY-D1056) in RAW264.7 cells. Demethylregelin has anti-inflammatory activities .
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- HY-149671
-
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Others
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Inflammation/Immunology
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Anti-inflammatory agent 63 is an anti-inflammatory agent that shows optimal inhibitory activity (EC50 = 5.33±0.57 μM) against the production of nitric oxide (NO) induced by lipopolysaccharide (LPS) in RAW264.7 cells .
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- HY-N12139
-
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NO Synthase
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Cancer
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Nitric oxide production-IN-1(Compound 1) is a inhibitor of NO Production which isolated from Tupistra chinensis. Nitric oxide production-IN-1(Compound 1) inhibits NO production in rat abdomen macrophages induced by lipopolysaccharide
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- HY-N10156
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-
- HY-N0625A
-
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|
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Alpinetin is a flavonoid isolated from cardamom and has anti-inflammatory activity. Alpinetin inhibits lipopolysaccharide (LPS)-induced inflammation, activates PPAR-γ, activates Nrf2, and inhibits TLR4 expression to protect LPS-induced renal injury .
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- HY-18734A
-
-
- HY-18734
-
-
- HY-B0289S
-
-
- HY-136741
-
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IKK
|
Inflammation/Immunology
|
BOT-64 is an inhibitory κB (IκB) kinase β (IKKβ) inhibitor with an IC50 of 1 µM. BOT-64 blocks lipopolysaccharide-induced nuclear factor-κB activation and nuclear factor-κB-regulated inflammatory gene transcription .
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- HY-N8812
-
|
NO Synthase
|
Inflammation/Immunology
|
19-[(β-D-Glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide, the metabolite of Neoandrographolide, inhibits nitric oxide (NO) production in lipopolysaccharide-activated macrophages .
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- HY-N1186
-
|
|
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Tachioside inhibits nitric oxide production in lipopolysaccharide (HY-D1056)-stimulated RAW 264.7 cells with IC50 value of 12.14 μM. Tachioside has anti-obesity, antioxidant and α-glucosidase inhibitory activities .
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-
- HY-N0602
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Chikusetsusaponin I; Panaxoside Rg2; Prosapogenin C2
|
NF-κB
Amyloid-β
|
Cardiovascular Disease
Neurological Disease
Cancer
|
Ginsenoside Rg2 is one of the major active components of ginseng. Ginsenoside Rg2 inhibits VCAM-1 and ICAM-1 expressions stimulated with lipopolysaccharide (LPS). Ginsenoside Rg2 also reduces Aβ1-42 accumulation.
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- HY-12085S
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CC-10004-d5
|
|
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Apremilast-d5 is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM[1].
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- HY-N10175
-
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Fungal
Endogenous Metabolite
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Inflammation/Immunology
|
Berkeleyacetal C, a meroterpenoid compound, shows favorable activity of inhibiting nitrogen oxide (NO) production of macrophages stimulated by lipopolysaccharide (LPS). Berkeleyacetal C exerts anti-inflammatory effects via inhibiting NF-κB, ERK1/2 and IRF3 signaling pathways .
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- HY-N3246
-
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NO Synthase
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Inflammation/Immunology
|
Morachalcone A is a naturally-occurring aromatase inhibitor (IC50=4.6 mM). Morachalcone A is also a plants metabolite with potential anti-inflammatory and anticancer activity. Morachalcone A inhibits Lipopolysaccharide (HY-D1056)-induced nitric oxide production .
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-
- HY-N3552
-
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NF-κB
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Inflammation/Immunology
|
Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages .
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- HY-W573700
-
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Others
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Others
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Methyl everninate is the major constituent of the deuterochloroform. Methyl everninate, rhodomollosides A and B are the derivatives of Methyl everninate, with cytotoxicity against RAW264.7 cells. Both of they shows inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model .
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- HY-N3383
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Ligstroside
|
Mitochondrial Metabolism
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Neurological Disease
|
Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer's disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages .
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- HY-151402
-
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Bacterial
|
Infection
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Antimicrobial agent-8 (Compound 15) is a potent antimicrobial agent, and shows potent antimicrobial activity with an MIC range of 2-8 μg/mL against Gram-negative and Gram-positive bacteria. Antimicrobial agent-8 shows anti-inflammatory activity against lipopolysaccharide-induced inflammation.
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-
- HY-108670
-
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P2X Receptor
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Inflammation/Immunology
|
AZ11645373 is a highly selective and potent antagonist at human but not rat P2X7 receptors,AZ11645373 inhibits ATP-evoked IL-1β release from lipopolysaccharide-activated THP-1 cells , with an IC50 value of 90 nM .
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- HY-149816
-
-
- HY-151401
-
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Bacterial
|
Infection
|
Antimicrobial agent-7 (Compound 12) is a potent antimicrobial agent, and shows potent antimicrobial activity with an MIC range of 2-8 μg/mL against Gram-negative and Gram-positive bacteria. Antimicrobial agent-7 shows anti-inflammatory activity against lipopolysaccharide-induced inflammation .
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- HY-148591
-
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Epigenetic Reader Domain
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Inflammation/Immunology
|
GSK761 is a selective inhibitor of speckled 140 kDa (SP140) with an IC50 value of 77.79 nM. GSK761 reduces monocyte-to-inflammatory macrophage differentiation and lipopolysaccharide (LPS)-induced inflammatory activation. GSK761 induces the production of CD206 + regulatory macrophages by inhibiting SP140 .
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- HY-111613
-
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Calcium Channel
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Cancer
|
Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients .
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- HY-103639
-
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Toll-like Receptor (TLR)
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Inflammation/Immunology
|
M62812 (free base) is a toll-like receptor 4 (TLR4) signal transduction inhibitor. M62812 can suppress endothelial cell and leukocyte activation and prevents lethal septic shock in mice. M62812 can be used for the research of sepsis .
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- HY-103639A
-
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Toll-like Receptor (TLR)
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Infection
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M62812 is a toll-like receptor 4 (TLR4) signaling inhibitor. M62812 inhibits endothelial and leukocyte activation and prevents lethal septic shock in mice. M62812 can reduces LPS-induced coagulation and inflammatory responses. M62812 can be used for the research of sepsis .
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- HY-125176
-
G907
1 Publications Verification
|
Bacterial
|
Infection
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G907 is a selective antagonist of ATP-binding cassette (ABC) transporter MsbA with anti-microbial activity. G907 inhibits E. coli MsbA with an IC50 value of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket .
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-
- HY-13982
-
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NF-κB
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Metabolic Disease
Inflammation/Immunology
Cancer
|
JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC50 of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .
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-
- HY-N6927
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Coleonol B
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TNF Receptor
Interleukin Related
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Inflammation/Immunology
|
Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis .
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-
- HY-N11657
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Sanggenone A
|
NF-κB
Keap1-Nrf2
|
Inflammation/Immunology
|
Sanggenon A (Sanggenone A) exerts anti-inflammatory effects by regulating NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells. Sanggenon A markedly inhibits the Lipopolysaccharide (LPS; HY-D1056)-induced production of nitric oxide .
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-
- HY-N4155
-
|
EBV
HIV Protease
HSV
|
Infection
Cancer
|
2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid, a natural ursane-type triterpene, is a potent inhibitor of HIV protease (HIV Protease). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is also an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid displays an inhibitory activity against nitric oxide production in Lipopolysaccharide (Lipopolysaccharides)-activated RAW 264.7 cells .
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-
- HY-113829
-
|
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
|
Valnemulin is an orally active broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria, anaerobic bacteria, Mycoplasma, and Spirochetes. Valnemulin ameliorates enteric diseases, acute polyarthritis and enzootic pneumonia in pigs . Valnemulin exhibits anti-inflammatory efficacy against lipopolysaccharide (HY-D1056)-induced lung injury .
|
-
- HY-12511
-
|
p38 MAPK
|
Inflammation/Immunology
|
SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC50 = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .
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-
- HY-108641
-
|
p38 MAPK
|
Inflammation/Immunology
|
SKF-86002 dihydrochloride is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 dihydrochloride inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC50 = 1 μM). SKF-86002 dihydrochloride inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .
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-
- HY-N2939
-
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Others
|
Others
|
Bis-5,5-Nortrachelogenin is isolated from active extract of root of Wikstroemia indica. Bis-5,5-Nortrachelogenin inhibits nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-γ(IFN-γ) activated murine macrophage-like cell line, RAW 264.7 with an IC50 value of 48.6 mM .
|
-
- HY-144281
-
|
Bacterial
|
Infection
|
MsbA-IN-3 (compound 31) is a potent and highly selective MsbA inhibitor with an IC50 value of 2 nM. MsbA-IN-3 has inhibitory activity against Escherichia coli with a MIC of 35 μM .
|
-
- HY-144282
-
|
Bacterial
|
Infection
|
MsbA-IN-4 (compound 32) is a potent and highly selective MsbA inhibitor with an IC50 value of 3 nM. MsbA-IN-4 has inhibitory activity against Escherichia coli with a MIC of 12 μM .
|
-
- HY-N8371
-
|
NO Synthase
COX
Interleukin Related
TNF Receptor
|
Inflammation/Immunology
|
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression .
|
-
- HY-142125
-
|
Xanthine Oxidase
Reactive Oxygen Species
Apoptosis
|
Inflammation/Immunology
Cancer
|
Broussochalcone A is an antioxidant and an inhibitor of Xanthine Oxidase (IC50=2.21 μM), with free radical scavenging activity. Broussochalcone A inhibits iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (LPS) -activated macrophages. Broussochalcone A also induces Apoptosis of human renal carcinoma cells by increasing ROS levels and activating FOXO3 signaling pathways .
|
-
- HY-N3814
-
|
Others
|
Inflammation/Immunology
|
ent-16β,17-Dihydroxykauran-19-oic acid is an anti-inflammatory agent, which can be isolated from Siegesbeckia pubescens herb. ent-16β,17-Dihydroxykauran-19-oic acid inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia .
|
-
- HY-14648A
-
-
- HY-42682
-
D-Galactosamine hydrochloride
|
Others
|
Inflammation/Immunology
|
D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D(+)-Galactosamine hydrochloride intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure .
|
-
- HY-N0602R
-
Chikusetsusaponin I(Standard); Panaxoside Rg2(Standard); Prosapogenin C2 (Standard)
|
NF-κB
Amyloid-β
|
Cardiovascular Disease
Neurological Disease
Cancer
|
Ginsenoside Rg2 (Standard) is the analytical standard of Ginsenoside Rg2. This product is intended for research and analytical applications. Ginsenoside Rg2 is one of the major active components of ginseng. Ginsenoside Rg2 inhibits VCAM-1 and ICAM-1 expressions stimulated with lipopolysaccharide (LPS). Ginsenoside Rg2 also reduces Aβ1-42 accumulation.
|
-
- HY-155572
-
|
Keap1-Nrf2
|
Inflammation/Immunology
|
Nrf2 activator-8 (compound 10e) is a Nrf2 activator (EC50=37.9 nM). Nrf2 activator-8 exhibits remarkable antioxidant and anti-inflammatory effects in BV-2 microglial cells. Nrf2 activator-8 can significantly restore spatial memory deficits in a mouse model of lipopolysaccharide (LPS)-induced neuroinflammation .
|
-
- HY-N7012
-
5-Hydroxy-3',4',7-trimethoxyflavone
|
TNF Receptor
Interleukin Related
COX
|
Inflammation/Immunology
|
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2 .
|
-
- HY-P2458
-
|
Bacterial
|
Infection
|
CAP18 (rabbit) is a 37 amino acids antimicrobial peptide originally isolated from rabbit granulocytes. CAP18 (rabbit) has broad antimicrobial activity against both Gram-positive (IC50, 130-200 nM) and Gram-negative (IC50, 20-100 nM) bacteria. CAP18 (rabbit) has the potential for bacterial sepsis research .
|
-
- HY-112226
-
|
Caspase
Drug Metabolite
|
Inflammation/Immunology
|
VRT-043198, the agent metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 exhibits Ki values of 0.8 nM and 0.6 nM for ICE/caspase-1 and caspase-4, respectively .
|
-
- HY-N8435
-
-
- HY-149426
-
|
Sirtuin
|
Inflammation/Immunology
|
SIRT5 inhibitor 7 (compound 58) is a substrate-competitive and selective SIRT5 inhibitor with anti-inflammatory activity. SIRT5 inhibitor 7 has renal protective effects and regulates protein succinylation and the release of pro-inflammatory cytokines. SIRT5 inhibitor 7 has in vivo activity in AKI mouse models of lipopolysaccharide (LPS) and cecal ligation/perforation (CLP)-induced sepsis-related acute kidney injury .
|
-
- HY-14648S1
-
-
- HY-14648S2
-
-
- HY-B1201
-
3,3',5-Triiodothyroacetic acid
|
Flavivirus
Thyroid Hormone Receptor
TNF Receptor
|
Endocrinology
|
Tiratricol is an orally available thyroid hormone analog that inhibits pituitary thyroid-stimulating hormone secretion. Tiratricol is an intracellular toxin neutralizer that inhibits LPS and lipid A cytotoxicity with IC50s of 20 μM and 32 μM, respectively. Tiratricol reduces TNF production in lipopolysaccharide-stimulated macrophages. Tiratricol also has antiviral activity and is an inhibitor of yellow fever virus (Flavivirus). It can bind to the RdRp domain of the viral NS5 protein to hinder YFV replication. .
|
-
- HY-14648S
-
-
- HY-128598
-
|
Toll-like Receptor (TLR)
|
Inflammation/Immunology
Cancer
|
MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively .
|
-
- HY-14648R
-
Hexadecadrol(Standard); Prednisolone F (Standard)
|
Glucocorticoid Receptor
SARS-CoV
Autophagy
Complement System
Mitophagy
Bacterial
Antibiotic
ADC Cytotoxin
|
Infection
Inflammation/Immunology
Endocrinology
Cancer
|
Dexamethasone (Standard) is the analytical standard of Dexamethasone. This product is intended for research and analytical applications. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
|
-
- HY-163355
-
|
COX
Lipoxygenase
NF-κB
|
Inflammation/Immunology
|
COX-2/15-LOX-IN-5 (Compound 4f) is a dual inhibitor of COX-2/15-LOX. COX-2/15-LOX-IN-5 attenuates increased NF-κB activation in RAW 264.7 macrophages mediated by lipopolysaccharide (HY-D1056). COX-2/15-LOX-IN-5 has anti-inflammatory and antioxidant activities .
|
-
- HY-14648AR
-
Dexamethasone 21-acetate (Standard); Hexadecadrol acetate (Standard)
|
Glucocorticoid Receptor
Autophagy
Mitophagy
Bacterial
SARS-CoV
Antibiotic
Complement System
ADC Cytotoxin
|
Inflammation/Immunology
Endocrinology
Cancer
|
Dexamethasone acetate (Standard) is the analytical standard of Dexamethasone acetate. This product is intended for research and analytical applications. Dexamethasone acetate (Dexamethasone 21-acetate) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
|
-
- HY-13717
-
IRX4204; NRX194204; VTP 194204
|
RAR/RXR
Apoptosis
|
Inflammation/Immunology
Cancer
|
AGN194204 (IRX4204) is an orally active and selective RXR agonist with Kd values 0.4 nM, 3.6 nM and 3.8 nM and EC50s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively. AGN194204 is inactive against RAR. AGN194204 has anti-inflammatory and anticarcinogenic actions .
|
-
- HY-121892
-
|
Liposome
|
Neurological Disease
|
(Z)-KC02 is an inhibitor of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC). (Z)-KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z)-KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo .
|
-
- HY-161255
-
|
NO Synthase
|
Inflammation/Immunology
|
3,4-DAA is an orally active Anthranilic acid derivative with potent immunosuppressive activities. 3, 4-DAA can alleviate the severity of colitis through inhibiting Th1 cells response, promoting Th2 cytokines expression and inducing CD4 +CD25 + T cells expression . 3,4-DAA suppressed expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) release from EOC20 cells induced by IFN-γ and Lipopolysaccharide .
|
-
- HY-107427
-
|
MAPKAPK2 (MK2)
p38 MAPK
|
Inflammation/Immunology
|
PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect .
|
-
- HY-163151
-
|
PI3K
Akt
p38 MAPK
|
Neurological Disease
Inflammation/Immunology
|
JE-133 is an optically active isochromane-2H-chromene conjugate. JE-133 exhibits antioxidant and anti-inflammatory activities. JE-133 is a neuroprotective agent that effectively inhibits neuronal oxidative damage associated with PI3K/Akt and MAPK signaling pathways. JE-133 can also inhibit lipopolysaccharide (LPS) (HY-D1056)-induced neuroinflammation by regulating JAK/STAT and Nrf2 signaling pathways .
|
-
- HY-14648S3
-
|
Isotope-Labeled Compounds
Glucocorticoid Receptor
SARS-CoV
Autophagy
Complement System
Mitophagy
Bacterial
Antibiotic
|
|
Dexamethasone-4,6α,21,21-d4 is the deuterium labeled Dexamethasone-4,6α,21,21. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
|
-
- HY-14648S5
-
Hexadecadrol-d3-1; Prednisolone F-d3-1
|
Isotope-Labeled Compounds
|
Cancer
|
Dexamethasone-d3-1 (Hexadecadrol-d3-1; Prednisolone F-d3-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
|
-
- HY-146547
-
|
Interleukin Related
TNF Receptor
|
Inflammation/Immunology
|
Anti-inflammatory agent 17 is a potent and orally active anti-inflammatory agent. Anti-inflammatory agent 17 inhibits the release of IL-6 and TNF-α in vitro experiments without cytotoxicity. Anti-inflammatory agent 17 exhibits anti-inflammatory activity in vivo. Anti-inflammatory agent 17 has the potential for the research of Acute lung injury (ALI) .
|
-
- HY-117718
-
Tyrphostin AG957; NSC 654705
|
Bcr-Abl
|
Cancer
|
AG957 (Tyrphostin AG957;NSC 654705) is a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity . AG957 is a bcr/abl kinase inhibitor with an IC50 of 2.9 μM for p210 bcr/abl autokinase activity .
|
-
- HY-113509
-
LXA4
|
Interleukin Related
Endogenous Metabolite
|
Inflammation/Immunology
|
Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties . Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways . Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM .
|
-
- HY-125516
-
|
Others
|
Others
Inflammation/Immunology
|
MCTR3 is a potent cytokine of pro-resolving mediating maresin conjugates in tissue regeneration (MCTR), which reduces the inflammatory response and promotes the tissue regeneration. MCTR3 exhibits potency in ameliorating LPS-induced acute lung injury and arthritis .
|
-
- HY-116807
-
DHLA
|
Reactive Oxygen Species
|
Neurological Disease
Inflammation/Immunology
|
Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical . Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression .
|
-
- HY-W082785A
-
-
- HY-103251
-
LpxC-4
|
Antibiotic
Bacterial
|
Infection
|
PF-5081090 (LpxC-4) is a potent LpxC inhibitor, is a rapidly bactericidal with broad-spectrum activity. PF-5081090 serves as a regulator of lipid A biosynthesis in Gram-negative pathogens .
|
-
Cat. No. |
Product Name |
Type |
-
- HY-D1056
-
LPS
|
Biochemical Assay Reagents
|
Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells . This product is derived from Escherichia coli O55:B5. Lipopolysaccharides induces secretion of cell migrasome .
|
-
- HY-121892
-
|
Drug Delivery
|
(Z)-KC02 is an inhibitor of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC). (Z)-KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z)-KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo .
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P3496
-
|
Pyroptosis
|
Inflammation/Immunology
|
Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis .
|
-
- HY-P1674A
-
POL7080 TFA
|
Bacterial
Antibiotic
|
Infection
|
Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with MIC50 and MIC90 values both of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance .
|
-
- HY-P1674
-
POL7080
|
Bacterial
Antibiotic
|
Infection
|
Murepavadin (POL7080), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with both MIC50 and MIC90 values of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance .
|
-
- HY-P10159
-
|
Bacterial
|
Infection
|
Diplacol ia a natural compound from from Mimulus clevelandi and shows potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production .
|
-
- HY-P2458
-
|
Bacterial
|
Infection
|
CAP18 (rabbit) is a 37 amino acids antimicrobial peptide originally isolated from rabbit granulocytes. CAP18 (rabbit) has broad antimicrobial activity against both Gram-positive (IC50, 130-200 nM) and Gram-negative (IC50, 20-100 nM) bacteria. CAP18 (rabbit) has the potential for bacterial sepsis research .
|
-
- HY-K1044
-
|
Polymixin B is a mixture of B1 and B2 polypeptides obtained from different strains of Bacillus polymyxa, with antibacterial activity against gram-negative bacteria. It can bind lipopolysaccharide (LPS) of the outer membrane of gram-negative bacteria and disrupts the cytoplasmic membrane by inducing large pores to allow nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-D1056
-
-
-
- HY-106947
-
-
-
- HY-N8277
-
-
-
- HY-119720
-
-
-
- HY-N9297
-
-
-
- HY-N8160
-
-
-
- HY-N3182
-
-
-
- HY-N10066
-
-
-
- HY-N6946
-
-
-
- HY-N11028
-
-
-
- HY-A0089
-
-
-
- HY-N5015
-
-
-
- HY-N3473
-
-
-
- HY-N9675
-
-
-
- HY-N10275
-
-
-
- HY-N10445
-
-
-
- HY-N4243
-
-
-
- HY-N10274
-
-
-
- HY-N10446
-
-
-
- HY-N11544
-
-
-
- HY-N11548
-
-
-
- HY-N8129
-
-
-
- HY-N2391
-
-
-
- HY-N10277
-
-
-
- HY-N2556
-
-
-
- HY-N12429
-
-
-
- HY-N1695
-
-
-
- HY-N12139
-
-
-
- HY-N10156
-
-
-
- HY-N0602
-
-
-
- HY-N10175
-
-
-
- HY-N3246
-
-
-
- HY-N3552
-
-
-
- HY-W573700
-
-
-
- HY-N3383
-
-
-
- HY-N6927
-
-
-
- HY-N11657
-
-
-
- HY-N4155
-
|
Rosaceae
Rosa cymosa (L.) Tratt.
Plants
|
EBV
HIV Protease
HSV
|
2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid, a natural ursane-type triterpene, is a potent inhibitor of HIV protease (HIV Protease). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is also an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid displays an inhibitory activity against nitric oxide production in Lipopolysaccharide (Lipopolysaccharides)-activated RAW 264.7 cells .
|
-
-
- HY-113829
-
|
Structural Classification
Natural Products
Animals
Source classification
|
Antibiotic
Bacterial
|
Valnemulin is an orally active broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria, anaerobic bacteria, Mycoplasma, and Spirochetes. Valnemulin ameliorates enteric diseases, acute polyarthritis and enzootic pneumonia in pigs . Valnemulin exhibits anti-inflammatory efficacy against lipopolysaccharide (HY-D1056)-induced lung injury .
|
-
-
- HY-N2939
-
-
-
- HY-N8371
-
-
-
- HY-142125
-
-
-
- HY-N3814
-
-
-
- HY-42682
-
-
-
- HY-N0602R
-
-
-
- HY-N7012
-
5-Hydroxy-3',4',7-trimethoxyflavone
|
Galinsoga parviflora Cav.
Flavonoids
Monophenols
Classification of Application Fields
Flavones
Labiatae
Source classification
Phenols
Plants
Disease Research Fields
Inflammation/Immunology
|
TNF Receptor
Interleukin Related
COX
|
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2 .
|
-
-
- HY-113509
-
-
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-14648S
-
|
Dexamethasone-d5 is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses[1][2].
|
-
-
- HY-14648S3
-
|
Dexamethasone-4,6α,21,21-d4 is the deuterium labeled Dexamethasone-4,6α,21,21. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
|
-
-
- HY-B0289S
-
|
Erdosteine- 13C4 is a 13C-labeled Erdosteine. Erdosteine inhibits lipopolysaccharide (LPS)-induced NF-κB activation[1][2]. Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects[3].
|
-
-
- HY-14648S1
-
|
Dexamethasone-d5-1 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
|
-
-
- HY-14648S2
-
|
Dexamethasone-d4 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
|
-
-
- HY-14648S5
-
|
Dexamethasone-d3-1 (Hexadecadrol-d3-1; Prednisolone F-d3-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
|
-
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