MMAD (Synonyms: Demethyldolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10)

Cat. No.: HY-15581 Purity: 99.94%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

MMAD is a potent tubulin inhibitor, is a toxin payload in antibody agent conjugates (ADCs).

For research use only. We do not sell to patients.

MMAD Chemical Structure

CAS No. : 203849-91-6

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Other Forms of MMAD:

MMAD-d₈ In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

MMAD is a potent tubulin inhibitor, is a toxin payload in antibody agent conjugates (ADCs).

IC₅₀ & Target

Auristatin

In Vitro

MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

771.06

Formula

C₄₁H₆₆N₆O₆S

CAS No.

203849-91-6

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H](C)[C@H]([C@]1([H])CCCN1C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C([C@@H](NC([C@@H](N(C)[H])C(C)C)=O)C(C)C)=O)C)=O)OC)N[C@@H](CC2=CC=CC=C2)C3=NC=CS3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : 24.5 mg/mL (31.77 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2969 mL	6.4846 mL	12.9692 mL
5 mM	0.2594 mL	1.2969 mL	2.5938 mL
10 mM	0.1297 mL	0.6485 mL	1.2969 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.94%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (253 KB) RP-HPLC (222 KB)

Handling Instructions (2659 KB)

References

[1]. Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8(2):114-9. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2969 mL	6.4846 mL	12.9692 mL	32.4229 mL
	5 mM	0.2594 mL	1.2969 mL	2.5938 mL	6.4846 mL
	10 mM	0.1297 mL	0.6485 mL	1.2969 mL	3.2423 mL
	15 mM	0.0865 mL	0.4323 mL	0.8646 mL	2.1615 mL
	20 mM	0.0648 mL	0.3242 mL	0.6485 mL	1.6211 mL
	25 mM	0.0519 mL	0.2594 mL	0.5188 mL	1.2969 mL
	30 mM	0.0432 mL	0.2162 mL	0.4323 mL	1.0808 mL

MMAD Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMAD203849-91-6Demethyldolastatin 10 Monomethylauristatin D Monomethyl Dolastatin 10Demethyldolastatin10Demethyldolastatin-10Monomethyl Dolastatin10Monomethyl Dolastatin 10Monomethyl Dolastatin-10Microtubule/TubulinADC CytotoxinADC PayloadInhibitorinhibitorinhibit

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