2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. 5-HT Receptor Potassium Channel Cytochrome P450
  4. Mosapride citrate

Mosapride citrate  (Synonyms: TAK-370 citrate; AS-4370 citrate)

Cat. No.: HY-B0189A Purity: 99.96%
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Mosapride citrate is an orally active gastroenterokinetic compound. Mosapride citrate is a 5HT4 agonist. Mosapride citrate is a CYP inducer. Mosapride citrate has a concentration-dependent inhibitory effect on Kv4.3, and its IC50 value is 15.2 μM. Mosapride citrate can be used in the study of gastrointestinal diseases.

For research use only. We do not sell to patients.

Mosapride citrate Chemical Structure

Mosapride citrate Chemical Structure

CAS No. : 112885-42-4

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 61 In-stock
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10 mg USD 55 In-stock
50 mg USD 149 In-stock
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Based on 3 publication(s) in Google Scholar

Other Forms of Mosapride citrate:

Mosapride citrate Related Antibodies

Top Publications Citing Use of Products

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP3A4 CYP17A1

  • Biological Activity

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Description

Mosapride citrate is an orally active gastroenterokinetic compound. Mosapride citrate is a 5HT4 agonist. Mosapride citrate is a CYP inducer. Mosapride citrate has a concentration-dependent inhibitory effect on Kv4.3, and its IC50 value is 15.2 μM. Mosapride citrate can be used in the study of gastrointestinal diseases[1][2][3][4][5][6][7].

IC50 & Target

5-HT4 Receptor

 

In Vitro

Mosapride citrate (1-100 nM) significantly increases the average amplitude of proximal and distal colon contraction, and shortens the transport time of proximal and distal colon in guinea-pig[3].
Mosapride citrate (869 ng/mL, 48 h) increases the induction ability of Cytochrome P450 (CYP1A2, 2B6 and 3A4) in human hepatocytes (HMC424, 478 and 493)[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mosapride citrate Related Antibodies
In Vivo

Mosapride citrate (0.3-3 mg/kg or 30 mg/kg, p.o) promotes gastric empting rats in a dose-dependent manner. Gastric emptying was significantly inhibited when the dose was 30 mg/kg[5].
Mosapride citrate (0.5 mg/kg, p.o) can relieve NSAIDS induced ulcer by activating 5-HT4 receptor in rats[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSAID-induced experimental ulcer model[6]
Dosage: 0.25, 0.5 , 0.75 mg/kg
Administration: p.o
Result: Inhibited the mucosal damage.
Clinical Trial
Molecular Weight

614.02

Formula

C27H33ClFN3O10
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC1CN(CC2=CC=C(F)C=C2)CCO1)C3=CC(Cl)=C(N)C=C3OCC.O=C(CC(C(O)=O)(O)CC(O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (162.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6286 mL 8.1431 mL 16.2861 mL
5 mM 0.3257 mL 1.6286 mL 3.2572 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.07 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (4.07 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6286 mL 8.1431 mL 16.2861 mL 40.7153 mL
5 mM 0.3257 mL 1.6286 mL 3.2572 mL 8.1431 mL
10 mM 0.1629 mL 0.8143 mL 1.6286 mL 4.0715 mL
15 mM 0.1086 mL 0.5429 mL 1.0857 mL 2.7144 mL
20 mM 0.0814 mL 0.4072 mL 0.8143 mL 2.0358 mL
25 mM 0.0651 mL 0.3257 mL 0.6514 mL 1.6286 mL
30 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.3572 mL
40 mM 0.0407 mL 0.2036 mL 0.4072 mL 1.0179 mL
50 mM 0.0326 mL 0.1629 mL 0.3257 mL 0.8143 mL
60 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.6786 mL
80 mM 0.0204 mL 0.1018 mL 0.2036 mL 0.5089 mL
100 mM 0.0163 mL 0.0814 mL 0.1629 mL 0.4072 mL
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Mosapride citrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mosapride112885-42-4TAK-370AS-4370TAK370TAK 370AS4370AS 43705-HT ReceptorPotassium ChannelCytochrome P450Serotonin Receptor5-hydroxytryptamine ReceptorKcsACYPs5-HT4AgonistCYPHMC424HMC478HMC493gastric emptying in ratgastrointestinal diseaseInhibitorinhibitorinhibit

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