1. Anti-infection
  2. Fungal
  3. N-563

N-563 is an analogue of deoxyspergualin with an immunostimulating activity,it promotes resistance to Candida albicans infection in mice.

For research use only. We do not sell to patients.

N-563 Chemical Structure

N-563 Chemical Structure

CAS No. : 140686-92-6

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Based on 1 publication(s) in Google Scholar

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Description

N-563 is an analogue of deoxyspergualin with an immunostimulating activity,it promotes resistance to Candida albicans infection in mice. In vivo: The protective effect of the N-563 against C. albicans infection was investigated in normal and immunosuppressed mice. In normal mice, N-563 treatment at 10 mg/kg for 3 days prior to infection significantly prolonged the survival time. In immunosuppressed mice treated with a single dose of cyclophosphamide 4 days prior to infection, N-563 at 3 and 10 mg/kg for 3 days prior to infection also significantly prolonged the survival time of mice. In addition, it augmented the phagocytic activity of neutrophils and enhanced the delayed type hypersensitivity reaction against C. albicans. Coincidentally, N-563 appeared to protect against secondary infection with C. albicans in the delayed type hypersensitivity-positive mice.[1] N-563 was dissolved in physiological saline and filtered through a Millipore filter (0.22μm).[1]

Molecular Weight

359.42

Formula

C15H29N5O5

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCC(O)=O)CC(O)CNC(CCCCCCNC(N)=N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

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Purity & Documentation

Purity: ≥98.0%

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
N-563
Cat. No.:
HY-100751
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