2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Ondansetron hydrochloride dihydrate

Ondansetron hydrochloride dihydrate  (Synonyms: GR 38032 hydrochloride dihydrate; SN 307 hydrochloride dihydrate)

Cat. No.: HY-B0002A Purity: 99.03%
COA Handling Instructions

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Ondansetron (GR 38032) hydrochloride dehydrate is an orally active, highly selective and competitive 5-HT3 receptor antagonist (crosses the blood-brain barrier). Ondansetron hydrochloride dehydrate can be used in studies of preventing nausea and vomiting associated with cancer chemotherapy, radiation therapy and surgery.

For research use only. We do not sell to patients.

Ondansetron hydrochloride dihydrate Chemical Structure

Ondansetron hydrochloride dihydrate Chemical Structure

CAS No. : 103639-04-9

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Based on 7 publication(s) in Google Scholar

Other Forms of Ondansetron hydrochloride dihydrate:

Ondansetron hydrochloride dihydrate Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ondansetron (GR 38032) hydrochloride dehydrate is an orally active, highly selective and competitive 5-HT3 receptor antagonist (crosses the blood-brain barrier). Ondansetron hydrochloride dehydrate can be used in studies of preventing nausea and vomiting associated with cancer chemotherapy, radiation therapy and surgery[1][2].

IC50 & Target

5-HT3 Receptor

 

In Vivo

Ondansetron hydrochloride dehydrate (2 mg/kg; i.p.; single) blocks radiation sickness when combines with Dexamethasone (2 mg/kg) and CP-99,994 (15 mg/kg), in radiation-induced pica model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice of ICR strain (8-week-old; 30-36 g; radiation-induced pica model (kaolin ingestion behavior “pica” may be analogous to nausea and vomiting in mice))[1].
Dosage: 2 mg/kg
Administration: Intraperitoneal injection; single.
Result: Slightly reduced the radiation-induced kaolin consumption by dexamethasone to 48% of the control.
Showed good activity of blocking radiation sickness by combining with Dexamethasone (2 mg/kg) and CP-99,994 (15 mg/kg).
Clinical Trial
Molecular Weight

365.85

Formula

C18H24ClN3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(CN2C=CN=C2C)CCC(N3C)=C1C4=C3C=CC=C4.[H]Cl.O.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (273.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 16.67 mg/mL (45.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7334 mL 13.6668 mL 27.3336 mL
5 mM 0.5467 mL 2.7334 mL 5.4667 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.03%

COA (257 KB) HNMR (190 KB) LCMS (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.7334 mL 13.6668 mL 27.3336 mL 68.3340 mL
5 mM 0.5467 mL 2.7334 mL 5.4667 mL 13.6668 mL
10 mM 0.2733 mL 1.3667 mL 2.7334 mL 6.8334 mL
15 mM 0.1822 mL 0.9111 mL 1.8222 mL 4.5556 mL
20 mM 0.1367 mL 0.6833 mL 1.3667 mL 3.4167 mL
25 mM 0.1093 mL 0.5467 mL 1.0933 mL 2.7334 mL
30 mM 0.0911 mL 0.4556 mL 0.9111 mL 2.2778 mL
40 mM 0.0683 mL 0.3417 mL 0.6833 mL 1.7084 mL
DMSO 50 mM 0.0547 mL 0.2733 mL 0.5467 mL 1.3667 mL
60 mM 0.0456 mL 0.2278 mL 0.4556 mL 1.1389 mL
80 mM 0.0342 mL 0.1708 mL 0.3417 mL 0.8542 mL
100 mM 0.0273 mL 0.1367 mL 0.2733 mL 0.6833 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ondansetron hydrochloride dihydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ondansetron hydrochloride dihydrate103639-04-9GR 38032 hydrochloride dihydrateSN 307 hydrochloride dihydrate5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptornauseavomitingcancer chemotherapyradiationcancer surgeryInhibitorinhibitorinhibit

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