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  3. PEAQX tetrasodium hydrate

PEAQX tetrasodium hydrate  (Synonyms: NVP-AAM077 tetrasodium hydrate)

Cat. No.: HY-12294A Purity: ≥98.0%
COA Handling Instructions

PEAQX (NVP-AAM077) tetrasodium hydrate is a potent, selective and orally active NMDA antagonist, with IC50 values of 270 nM and 29600 nM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively.

For research use only. We do not sell to patients.

PEAQX tetrasodium hydrate Chemical Structure

PEAQX tetrasodium hydrate Chemical Structure

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 177 In-stock
Solution
10 mM * 1 mL in Water USD 177 In-stock
Solid
5 mg USD 144 In-stock
10 mg USD 240 In-stock
50 mg USD 768 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of PEAQX tetrasodium hydrate:

Top Publications Citing Use of Products

    PEAQX tetrasodium hydrate purchased from MedChemExpress. Usage Cited in: Neuroscience. 2018 Nov 1;391:1-12.  [Abstract]

    PP2 and NVP-AAM077 pretreatment decreases the expression level of Cleaved Caspase-3 significantly.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    PEAQX (NVP-AAM077) tetrasodium hydrate is a potent, selective and orally active NMDA antagonist, with IC50 values of 270 nM and 29600 nM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively[1].

    IC50 & Target

    NMDA Receptor

     

    In Vitro

    PEAQX (3 μM) produces similar caspase-3 activation, while NVP-AAM007 is approximately three-fold more potent[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    PEAQX (10-40 mg/kg) dose-dependently increased cortical caspase-3 activity following sub-chronic administration[2].
    PEAQX (10 and 20 mg/kg) shows enhanced locomotor activity in response to PCP challenge (4 mg/kg on PN28-35) compared to saline pretreatment (F3, 73=4.99)[2].
    PEAQX (10 mg/kg, ip) antagonizes the effects of PRE084 on CaMKIV-TORC1-CREB and BDNF, even for learning and memory impairment[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Timed, day 14 pregnant female Sprague-Dawley rats[2].
    Dosage: 10, 20 or 40 mg/kg.
    Administration: S.C.
    Result: Showed a sensitized locomotor response to PCP challenge on PN28-35.
    Animal Model: Timed, day 14 pregnant female Sprague-Dawley rats[2].
    Dosage: 4 mg/kg.
    Administration: I.P.
    Result: Did not significantly increase locomotor activity in rats treated sub-chronically with PEAQX on PN7, 9 and 11.
    Animal Model: 11-week old C57BL/6 mice[3].
    Dosage: 10 mg/kg.
    Administration: IP.
    Result: Reversed the effect of PRE084 (F3,78 = 10.446, p<0.01).
    Molecular Weight

    560.15

    Formula

    C17H15BrN3Na4O6P

    Appearance

    Solid

    Color

    Light yellow to khaki

    SMILES

    BrC1=CC=C([C@H](C)NC(P(O[Na])(O[Na])=O)C2=CC=CC3=C2N=C(O[Na])C(O[Na])=N3)C=C1.[H]O[H]

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 25.5 mg/mL (45.52 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7852 mL 8.9262 mL 17.8524 mL
    5 mM 0.3570 mL 1.7852 mL 3.5705 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (178.52 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: ≥98.0%

    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.7852 mL 8.9262 mL 17.8524 mL 44.6309 mL
    5 mM 0.3570 mL 1.7852 mL 3.5705 mL 8.9262 mL
    10 mM 0.1785 mL 0.8926 mL 1.7852 mL 4.4631 mL
    15 mM 0.1190 mL 0.5951 mL 1.1902 mL 2.9754 mL
    20 mM 0.0893 mL 0.4463 mL 0.8926 mL 2.2315 mL
    25 mM 0.0714 mL 0.3570 mL 0.7141 mL 1.7852 mL
    30 mM 0.0595 mL 0.2975 mL 0.5951 mL 1.4877 mL
    40 mM 0.0446 mL 0.2232 mL 0.4463 mL 1.1158 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    PEAQX tetrasodium hydrate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    PEAQX tetrasodium hydrate
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