2. Anti-infection
  3. HSV
  4. Penciclovir

Penciclovir  (Synonyms: BRL 39123; VSA 671)

Cat. No.: HY-17424 Purity: 99.90%
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Penciclovir (VSA 671) is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir shows anti-herpesvirus activity with no-toxic. Penciclovir preventes mortality in mouse.

For research use only. We do not sell to patients.

Penciclovir Chemical Structure

Penciclovir Chemical Structure

CAS No. : 39809-25-1

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of Penciclovir:

Penciclovir Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Penciclovir

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Penciclovir (VSA 671) is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir shows anti-herpesvirus activity with no-toxic. Penciclovir preventes mortality in mouse[1][2].

IC50 & Target[1]

HSV-1

0.5 μg/mL (EC50)

HSV-2

0.8 μg/mL (EC50)

In Vitro

Penciclovir (0-100 µg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 µg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively[1].
Penciclovir (0-100 µg/ml) shows no-toxic to uninfected human cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Penciclovir Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells
Concentration: 0-100 µg/ml
Incubation Time:
Result: Showed no-toxic with IC50s of >100, >100, 100, >100, 60, >100, >100, >100, >100, >100, >100, >100 for MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells, respectively.
In Vivo

Penciclovir (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Three-week-old female Balb/c mice[2]
Dosage: 100 mg/kg
Administration: S.c.; daily for 5 days
Result: Reduced virus titres in the respiratory organs of both w/t- and PR3-infected mice.
Clinical Trial
Molecular Weight

253.26

Formula

C10H15N5O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC(N)=NC2=C1N=CN2CCC(CO)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (98.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 2 mg/mL (7.90 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9485 mL 19.7426 mL 39.4851 mL
5 mM 0.7897 mL 3.9485 mL 7.8970 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (9.87 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (9.87 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.9485 mL 19.7426 mL 39.4851 mL 98.7128 mL
5 mM 0.7897 mL 3.9485 mL 7.8970 mL 19.7426 mL
DMSO 10 mM 0.3949 mL 1.9743 mL 3.9485 mL 9.8713 mL
15 mM 0.2632 mL 1.3162 mL 2.6323 mL 6.5809 mL
20 mM 0.1974 mL 0.9871 mL 1.9743 mL 4.9356 mL
25 mM 0.1579 mL 0.7897 mL 1.5794 mL 3.9485 mL
30 mM 0.1316 mL 0.6581 mL 1.3162 mL 3.2904 mL
40 mM 0.0987 mL 0.4936 mL 0.9871 mL 2.4678 mL
50 mM 0.0790 mL 0.3949 mL 0.7897 mL 1.9743 mL
60 mM 0.0658 mL 0.3290 mL 0.6581 mL 1.6452 mL
80 mM 0.0494 mL 0.2468 mL 0.4936 mL 1.2339 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Penciclovir Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Penciclovir39809-25-1BRL 39123 VSA 671BRL39123BRL-39123VSA671VSA 671VSA-671HSVHerpes simplex virusanti-herpesvirusno-toxicmortalityInhibitorinhibitorinhibit

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